First magic mushroom depression trial hits stumbling block
2013 04 08

By Kate Kelland | Reuters



The world’s first clinical trial designed to explore using a hallucinogen from magic mushrooms to treat people with depression has stalled because of British and European rules on the use of illegal drugs in research.

David Nutt, president of the British Neuroscience Association and professor of neuropsychopharmacology at Imperial College London, said he had been granted an ethical green light and funding for the trial, but regulations were blocking it.

"We live in a world of insanity in terms of regulating drugs," he told a neuroscience conference in London on Sunday.

He has previously conducted small experiments on healthy volunteers and found that psilocybin, the psychedelic ingredient in magic mushrooms, has the potential to alleviate severe forms of depression in people who don’t respond to other treatments.

Following these promising early results he was awarded a 550,000 pounds ($844,000) grant from the UK’s Medical Research Council to conduct a full clinical trial in patients.

But psilocybin is illegal in Britain, and under the United Nations 1971 Convention on Psychotropic Substances it is classified as a Schedule 1 drug - one that has a high potential for abuse and no recognized medical use.

This, Nutt explained, means scientists need a special license to use magic mushrooms for trials in Britain, and the manufacture of a synthetic form of psilocybin for use in patients is tightly controlled by European Union regulations.

Together, this has meant he has so far been unable to find a company able to make and supply the drug for his trial, he said.

"Finding companies who could manufacture the drug and who are prepared to go through the regulatory hoops to get the license, which can take up to a year and triple the price, is proving very difficult," he said.

Nutt said regulatory authorities have a "primitive, old-fashioned attitude that Schedule 1 drugs could never have therapeutic potential", despite the fact that his research and the work done by other teams suggests such drugs may help treat some patients with psychiatric disorders.

Psilocybin - or "magic" - mushrooms grow naturally around the world and have been widely used since ancient times for religious rites and also for recreation.

Researchers in the United States have seen positive results in trials using MDMA, a pure form of the party drug ecstasy, in treating post-traumatic stress disorder.

"What we are trying to do is to tap into the reservoir of under-researched illegal drugs to see if we can find new and beneficial uses for them in people whose lives are often severely affected by illnesses such as depression," Nutt said.

The proposed trial would involve 60 patients with depression who have failed two previous treatments.

During two or three controlled sessions with a therapist, half would be given a synthetic form of psilocybin, and the other 30 a placebo. They would have guided talking therapy to explore negative thinking and issues troubling them, and doctors would follow them up for at least a year.

Nutt secured ethical approval for the trial in March.

In previous research, Nutt found that when healthy volunteers were injected with psilocybin, the drug switched off a part of the brain called the anterior cingulate cortex, which is known to be overactive in people with depression.

"Even in normal people, the more that part of the brain was switched off under the influence of the drug, the better they felt two weeks later. So there was a relationship between that transient switching off of the brain circuit and their subsequent mood,", he said. "This is the basis on which we want to run the trial."

Article from: reuters.com












Tune into Red Ice Radio:

Jan Irvin - Hour 1 & 2 - Gordon Wasson & The Secret History of Magic Mushrooms

Jan Irvin - The Holy Mushroom

Graham Hancock - Ancient & Modern Civilization, Sacred Cities, Star Architecture & The Destiny of America

John Lash - Origin of Religion, Entheogens, Wasson & Black Magic Pharmacology

Hugh Newman - The Olmecs & Megalithic Cultures

Rick Strassman - DMT: The Spirit Molecule

Mitch Shultz - The Spirit Molecule

Graham Hancock - Entangled, Supernatural, Shamanism & The Origins of Consciousness

H.P. Albarelli Jr. - Project MKULTRA, LSD, CIA, Dr. Sidney Gottlieb & Occult Government Studies

Radio 3Fourteen:

Simon G. Powell - The Psilocybin Solution vs. Elite Psychedelic Psyops




Related Articles
Know Your Mushrooms
The Multi-Faceted Magic Mushroom , The Pinecone and the Pineal Gland
’Magic mushrooms’ ingredient may ease end-of-life anxiety
Czech Gov’t: "You May Keep 40 Magic Mushrooms At Home"
One Step Beyond - The Sacred Mushroom (Video)
Benefits of ’magic mushroom’ therapy long lasting
Medicinal Mushrooms
Paul Stamets: 6 ways mushrooms can save the world
Health Benefits Of Magic Mushrooms


Latest News from our Front Page

A Look at Theories About Elongated Skulls in Ancient Peru, Europe, Egypt
2014 07 31
Elongated skulls have been found in ancient burial grounds around the world. Many are the result of a practice of intentionally deforming the skull with binding applied during the early years of a child’s life. Some may be explained by natural deformity. Yet enough mystery is left in relation to some of the skulls for various theories to arise. Could the ...
EU on high alert as Germany accepts Ebola patients
2014 07 30
A German hospital has agreed to treat Ebola patients amid widespread fears of a possible outbreak of the deadly disease in Europe. Over 670 people have already been killed by the disease in West Africa with doctors struggling to control the epidemic. A German hospital in Hamburg agreed to accept patients following a request from the World Health Organization (WHO), Deutsche ...
Bolivia declares Israel terrorist regime
2014 07 30
Bolivia has declared Israel a “terrorist state” and revoked a visa exemption agreement with Tel Aviv in protest at the ongoing Israeli attacks on the besieged Gaza Strip. The move "means, in other words, we are declaring (Israel) a terrorist state," President Evo Morales said during talks with a group of educators in the city of Cochabamba ...
Pagan Traditions: Mysteries of medieval graffiti in England’s churches
2014 07 30
Medieval graffiti of straw kings, pentagrams, crosses, ships and "demon traps" have been offering a tantalising glimpse into England’s past. What do the pictures reveal about life in the Middle Ages? A project to record the graffiti, which began in Norfolk, has now been rolled out to other areas and is gradually spreading across England. Armed with just a torch and a ...
More Gigantic Holes Appear in Siberia’s ’End of the World’
2014 07 30
Is it the end of the world in Siberia’s ’End of the World’? Scientists suspect not, but they’re still investigating the strange and alarming holes that are swallowing up the Siberian north. This week two new holes have been discovered, and with similar characteristics as the first reported hole: a very deep shaft with smooth sides, debris surrounding the rim, and water ...
More News »