Alzheimer’s drug trial test used for 20 years appears worthless
2012 12 18

By Sherry Baker | NaturalNews.com

What if a test of thinking abilities used to analyze whether Big Pharma drugs can help slow or treat Alzheimer’s weren’t actually accurate? And what if researchers had been relying on this screwed up test for decade upon decade? As amazing as it sounds, that appears to be the case.

Research led by Plymouth University Peninsula Schools of Medicine and Dentistry concludes the cognitive test used in Alzheimer’s drug trials is flawed. It’s so flawed, in fact, that it doesn’t track changes in the early stages of memory robbing Alzheimer’s disease. Why is this so extraordinarily important? Because data from this key stage is necessary to show whether or not a new drug works.

The test in question is the Alzheimer’s Disease Assessment Scale Cognitive Behavior Section (ADAS Cog). Developed back in the 1980s, it’s made up of 11 component parts including memory tests, language skills, naming objects and responding to commands. Patients are scored on each section resulting in a single overall score. The lower the total score, the better their cognitive performances are supposed to be. Until now, the ADAS Cog test was considered sort of a "gold standard" for assessing changes in thinking abilities as Alzheimer’s supposedly starts to destroy a person’s memory.

But the new research, published as two studies in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, which investigates the role of the test, questions its effectiveness. The results show that the assumed-accurate-for-decades ADAS Cog doesn’t work to track changes in the early stages of Alzheimer’s. Based on their findings, the Plymouth-based research team is calling for urgent changes to the ADAS Cog test. They are also not ruling out the possible need to throw the whole thing out and start over with a new test, either.

"It is impossible to say precisely the extent to which the ADAS Cog’s flaws have undermined the numerous clinical trials in which it has been used," Professor Jeremy Hobart, who headed the study, said in a media statement.

"It has been used, unchanged, for many years and its apparent contribution to suboptimal trials has led a number of drug companies to rethink their strategies. However, it is very clear that in its current form the ADAS Cog underestimates cognitive differences between people and changes over time," Hobart added. "To determine if treatments, developed from painstaking years of research, work in expensive studies we need to invest in developing measurement instruments that are fit for purpose. This requires the routine use of different methods. In its current form, the ADAS Cog is not working in people with mild Alzheimer’s disease."

While the drug companies have made little progress coming up with ways to halt or reverse Alzheimer’s disease, there is research that suggests natural health approaches can help. For example, as Natural News has previously covered, scientist William B. Grant, PhD, of the Sunlight, Nutrition, and Health Research Center (SUNARC) has come up with a hypothesis about the cause of mind-robbing Alzheimer’s disease and other vascular dementias: vitamin D deficiency.

Sources:

http://www.eurekalert.org/pub_releases/2012-12/uop-fia121412.php
http://www.naturalnews.com/026392_Vitamin_D_Alzheimers_disease.html
http://www.naturalnews.com/Alzheimers.html



Article from: naturalnews.com



Related Articles
Coconut Oil Touted as Alzheimer’s Remedy
GPS shoes for Alzheimer’s patients
Curry may prevent Alzheimer’s disease expert says
Earliest signs of Alzheimer’s found in 20-something year olds. Provides hints for prevention treatments


Latest News from our Front Page

James Foley Beheading: What They’re Not Telling You
2014 08 27
The latest poster child for military expansion in the middle east poses a host of disturbing questions. --- Experts: James Foley Beheading Video Likely Fake By Paul Joseph Watson| Infowars Forensic analysis confirms Infowars investigation that footage was staged as war propaganda Confirming Infowars’ analysis on Thursday, British forensic experts have concluded that the ISIS beheading video involving James Foley was in all likelihood ...
US forces move into Syria as Barack Obama paves way for airstrikes on ISIS
2014 08 27
US forces move into Syria: Obama paves way for airstrikes on ISIS after sending in spy planes - despite Assad warning that any attack will be seen as ’aggression’ Barack Obama has paved the way for airstrikes against ISIS targets in Syria after spy planes started operating in the country on his command, according to U.S officials. While the White ...
Stop creating a climate of fear!
2014 08 27
ok. listen up political correct people! if you’re someone who reflexively calls others “racists” or “neofascists” without first checking into whether or not they actually are, you need to STOP it, because you’re creating a climate of fear in which people are afraid to do their jobs. and now i’m not talking about some academics sitting comfortably in their ivy towers, ...
Gov. Jerry Brown to Mexican Illegals: ’You’re All Welcome in California’
2014 08 27
On Monday evening, California Governor Jerry Brown said all Mexicans, including illegal immigrants, are welcome in California. According to the Los Angeles Times, while introducing Mexican President Enrique Peña Nieto, who said America is "the other Mexico," Brown "spoke about the interwoven histories of Mexico and California." He "nodded to the immigrants in the room, saying it didn’t matter if ...
Election Posters in New Sweden
2014 08 27
Swedish prime minister Fredrik Reinfeldt has promised continued mass immigration at the expense of welfare reform and tax cuts. Reinfeldt’s Moderates party consequently does everything in their power to recruit immigrants’ votes. Placards for the forthcoming elections, widely distributed in immigrant-dominated enclaves in Sweden, has Arabic text, the language that now increasingly is dominating major parts of "New Sweden." In the ...
More News »