Sperm Viability Greatly Reduced in Offspring of Animals Treated With Common Antibiotic Tetracycline
2012 04 30

From: sciencedaily.com


Jeanne Zeh, lead author of a paper published in Nature’s open access journal Scientific Reports today, examines a pseudoscorpion using a microscope operated by graduate student, and one of the co-authors, Melvin Bonilla. Zeh is an assistant professor in the Department of Biology in the University of Nevada, Reno’s College of Science. The paper is the first to report the transgenerational effects of tetracycline.


In a paper published April 27 in Nature’s open access journal Scientific Reports, researchers at the University of Nevada, Reno report that male pseudoscorpions treated with the antibiotic tetracycline suffer significantly reduced sperm viability and pass this toxic effect on to their untreated sons. They suggest that a similar effect could occur in humans and other species.

"This is the first research to show a transgenerational effect of antibiotics," David Zeh, chair of the Department of Biology in the College of Science, said. "Tetracycline has a significant detrimental effect on male reproductive function and sperm viability of pseudoscorpions - reducing viability by up to 25 percent - and now we know that effect is passed on to the next generation. We didn’t see the effect in subsequent generations."

The research involved a three-generation study of the pseudoscorpion, Cordylochernes scorpioides, a small scorpion-like arachnid. To control for genetic influences, in the first generation, brothers and sisters from each of 21 broods were either treated with weekly doses of tetracycline from birth to adulthood or were reared as untreated controls. Subsequent generations were not treated with tetracycline. The antibiotic had no effect on male or female body size, sperm number or female reproduction, they found.

In the article, lead author and assistant biology professor Jeanne Zeh surmises that tetracycline may induce epigenetic changes in male reproductive tissues that may be passed to sons -- changes that do not alter the sequence of DNA but rather alter the way genes are expressed.

The broad-spectrum antibiotic tetracycline is commonly used in animal production, antimicrobial therapy, and for curing arthropods infected with bacterial endosymbionts such as Wolbachia. Despite more than six decades of therapeutic and agricultural use that has resulted in the evolution of widespread bacterial resistance, tetracycline is still commonly used as an additive in animal feed and as an accessible antimicrobial therapy in developing countries.

The research involved University of Nevada, Reno undergraduate and graduate students and was part of a project, funded by the National Science Foundation, which is investigating factors contributing to low male fertility.

Source: sciencedaily.com



Related Articles
Home Sperm Test Kit to Hit Drugstore Shelves
Wi-Fi kills sperm
Scientists grow sperm in a lab
Eugenics - Human Sperm Created in British Lab


Latest News from our Front Page

France delivered arms to Syrian rebels, Hollande confirms
2014 08 22
President Francois Hollande said on Thursday that France had delivered weapons to rebels battling the Syrian regime of Bashar al-Assad “a few months ago.” The deliveries took place “a few months ago, when the Syrian rebels had to face both the armies of the dictator Bashar al-Assad and this terrorist group Islamic State,” Hollande told reporters on a tour of the ...
Brooklyn DA exposes hidden Child Sexual Abuse in the Orthodox Jewish Community
2014 08 22
Comment: We all know that the sex abuse cases within the Catholic church have been plastered all over the media in the last 6-8 years, but when do you ever hear about the rapes, sexual molestation and child sex abuse cases within the jewish orthodox community? Is the media helping to cover it? Will they give the same treatment of ...
California’s Economic Collision Course: Immigration and Water
2014 08 22
You have heard it before: “As California goes, so goes the nation.” If that is the case, the national economy will be harmed for decades to come because of California’s misplaced priorities today. Indeed, by emphasizing high-speed rail over water and failing to deal with its debt crisis, California poses a long-term threat to our national economy and ...
ISIS offered to swap Foley for ’Lady Al Qaeda’ - neuroscientist MIT-graduate
2014 08 21
An MIT-educated neuroscientist terrorist known as ’Lady al Qaeda’ was named on a ’laundry list’ of demands from ISIS captors holding James Foley named, it was revealed today. Petite mother-of-three Aafia Siddiqui is currently serving 86 years in a Texas jail after being arrested with plans for a ’mass casualty attack’ in the US, including infecting people with Ebola and a ...
James Foley beheaded - Financed by USA
2014 08 21
John McCain is a traitorous piece of garbage. Last year McCain worked with the "Syrian Emergency Task Force" to help overthrow the Syrian government. Investigative work (see the detailed article below) revealed that this task force was just a front organization for AIPAC. McCain met with known terrorists, including the infamous al-Qaeda. Yeah, the terrorist organization that was behind 9/11 received aid ...
More News »