MIT Lincoln Laboratory researchers develop a technique to cure a broad range of viruses
Viral pathogens pose serious health threats worldwide. For clinical viruses such as HIV or hepatitis, emerging viruses such as avian or swine influenza, and highly lethal viruses such as Ebola or smallpox that might be used in bioterrorist attacks, relatively few therapeutics or prophylactics (preventatives) exist. Most therapeutics that do exist are highly specific for one virus, are ineffective against virus strains that become resistant to them, or have adverse effects on patients.
As part of the PANACEA (for Pharmacological Augmentation of Nonspecific Anti-pathogen Cellular Enzymes and Activities) project, researchers from MIT Lincoln Laboratory have developed and demonstrated a novel broad-spectrum antiviral approach, called DRACO (for Double-stranded RNA [dsRNA] Activated Caspase Oligomerizer). DRACO selectively induces apoptosis, or cell suicide, in cells containing any viral dsRNA, rapidly killing infected cells without harming uninfected cells. As a result, DRACO should be effective against virtually all viruses, rapidly terminating a viral infection while minimizing the impact on the patient.
Todd Rider invented the PANACEA and DRACO antiviral therapeutics, and previously invented the CANARY (Cellular Analysis and Notification of Antigen Risks and Yields) sensor for rapid pathogen detection and identification.
Dr. Todd Rider, senior staff scientist in MIT Lincoln Laboratory’s Chemical, Biological, and Nanoscale Technologies Group, invented PANACEA and the DRACO therapeutics, and led the team that developed them: Scott Wick, in charge of DRACO production; Christina Zook, in charge of cell testing; Tara Boettcher, in charge of mouse trials; and Jennifer Pancoast and Benjamin Zusman, who performed additional experiments.
In work reported in the journal PLoS ONE, DRACO was shown to be effective against all 15 viruses that the team has so far tested in cells, including cold viruses (rhinoviruses), H1N1 influenza strains, adenoviruses, a stomach virus (reovirus), a polio virus, dengue fever virus, and several members of hemorrhagic fever arenavirus and bunyavirus families. DRACO was also demonstrated to be nontoxic in 11 different cell types representing various species (e.g., humans, monkeys, mice) and organ types (e.g., heart, lung, liver, kidney). In addition, experiments demonstrated that DRACO not only is nontoxic to mice but also can save mice infected with a lethal dose of H1N1 influenza. Currently, the team is testing additional viruses in mice and beginning to get promising results with those as well.
The microscope images above show that DRACO successfully treats viral infections. In the left set of four photos, rhinovirus (the common cold virus) kills untreated human cells (lower left), whereas DRACO has no toxicity in uninfected cells (upper right) and cures an infected cell population (lower right). Similarly, in the right set of four photos, dengue hemorrhagic fever virus kills untreated monkey cells (lower left), whereas DRACO has no toxicity in uninfected cells (upper right) and cures an infected cell population (lower right).
Dr. Rider says that although more extensive testing is needed, "DRACO has the potential to revolutionize the treatment and prevention of virtually all viral diseases, including everything from the common cold to Ebola." He adds, "Because the antiviral activity of DRACO is so broad spectrum, we hope that it may even be useful against outbreaks of new or mutated viruses, such as the 2003 SARS [severe acute respiratory syndrome] outbreak."
This work is funded by a grant from the National Institute of Allergy and Infectious Diseases and the New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, with previous funding from the Defense Advanced Research Projects Agency, Defense Threat Reduction Agency, and Director of Defense Research & Engineering (now the Assistant Secretary of Defense for Research and Engineering).
Ed Comment: You got to love the symbolic acronyms that constantly are used by pharma, science and others.
Draco (lawgiver) - He replaced the prevailing system of oral law and blood feud by a written code to be enforced only by a court. Because of its harshness, this code also gave rise to the term "draconian". Listen to our program on the origins on the Law system.
Draco (constellation) - Among alien, UFO and conspiracy circles, it’s believed that a controling reptilian race comes from Draco, Alpa Draconis to be precise. Draco = dragon, snake, reptile etc.
You couldn’t make it up ...well, by now you could.
Netanyahu ‘spat in our face,’ White House officials said to say 2015-01-23 22:28
The White House’s outrage over Prime Minister Benjamin Netanyahu’s plan to speak before Congress in March — a move he failed to coordinate with the administration — began to seep through the diplomatic cracks on Friday, with officials telling Haaretz the Israeli leader had “spat” in President Barack Obama’s face.
“We thought we’ve seen everything,” the newspaper quoted an unnamed senior ...
Creators of martial law film "Grey State" found dead, reported as murder-suicide 2015-01-23 17:16 The creator of a not-yet-completed film about a central government takeover of society following a collapse and his family have been found dead in their Minnesota home, with authorities claiming that the deaths were the result of a murder-suicide.
As reported by the Star Tribune newspaper in Minneapolis, David Crowley, 29, his wife, Komel, 28, and their 5-year-old daughter were found ...
The Return of the Protected Jewish Minority in Europe 2015-01-23 2:53
Contrary to the standard narratives of Jewish ‘history,’ a prominent feature of the historical presence of Jews in Europe has been their protected status. The common context for this status was a symbiotic relationship between the Jewish minority and exploitative or tyrannical elites. As agents of the feared elite, as foreigners, as exploiters in their own right, and with interests ...
Truth Revealed: McCain’s ‘Moderate Rebels’ in Syria ARE ISIS 2015-01-23 1:50
Poor John McCain and Lindsey Graham, Washington’s real first couple. They only want to arm the ‘moderate opposition’ in Syria. Three years on, how come their master plan isn’t working, while ISIS has grown so strong?
Despite what media lauded as, “the largest demonstration in France’s history – bigger than liberation at the end of WWII!” (can you rightly compare the ...
European 'No-Go' Zones: Fact or Fiction? 2015-01-22 0:37
Comment: This is an interesting article about Muslim no-go Zones in Europe. However, keep in mind that the focus in this piece is not addressing the root of the problem, but a symptom of the problem. Yes, there is an issue with large Islamic colonies in Europe today, but the article mentions nothing about who has changed the immigration laws ...