Now scientists create a sheep that's 15% human
2007-04-03 0:00

By Claudia Joseph | mailonsunday.co.uk


Chimera: sheep have 15 per cent human cells and 85 per cent animal cells

Scientists have created the world's first human-sheep chimera - which has the body of a sheep and half-human organs.

The sheep have 15 per cent human cells and 85 per cent animal cells - and their evolution brings the prospect of animal organs being transplanted into humans one step closer.

Professor Esmail Zanjani, of the University of Nevada, has spent seven years and £5million perfecting the technique, which involves injecting adult human cells into a sheep's foetus.

He has already created a sheep liver which has a large proportion of human cells and eventually hopes to precisely match a sheep to a transplant patient, using their own stem cells to create their own flock of sheep.

The process would involve extracting stem cells from the donor's bone marrow and injecting them into the peritoneum of a sheep's foetus. When the lamb is born, two months later, it would have a liver, heart, lungs and brain that are partly human and available for transplant.

"We would take a couple of ounces of bone marrow cells from the patient,' said Prof Zanjani, whose work is highlighted in a Channel 4 programme tomorrow.

"We would isolate the stem cells from them, inject them into the peritoneum of these animals and then these cells would get distributed throughout the metabolic system into the circulatory system of all the organs in the body. The two ounces of stem cell or bone marrow cell we get would provide enough stem cells to do about ten foetuses. So you don't just have one organ for transplant purposes, you have many available in case the first one fails."

At present 7,168 patients are waiting for an organ transplant in Britain alone, and two thirds of them are expected to die before an organ becomes available.

Scientists at King's College, London, and the North East Stem Cell Institute in Newcastle have now applied to the HFEA, the Government's fertility watchdog, for permission to start work on the chimeras.

But the development is likely to revive criticisms about scientists playing God, with the possibility of silent viruses, which are harmless in animals, being introduced into the human race.

Dr Patrick Dixon, an international lecturer on biological trends, warned: "Many silent viruses could create a biological nightmare in humans. Mutant animal viruses are a real threat, as we have seen with HIV."

Animal rights activists fear that if the cells get mixed together, they could end up with cellular fusion, creating a hybrid which would have the features and characteristics of both man and sheep. But Prof Zanjani said: "Transplanting the cells into foetal sheep at this early stage does not result in fusion at all."

Article from: http://www.mailonsunday.co.uk/pages/live/
articles/news/news.html?in_article_id=444436&in_page_id=1770&in_a_source=



Related Articles
Science's new blend mixes man and beast
Cyborg Superman, Transhumanism and the Nephilim
Human Cells + Animal Cells = ?
Why Embryonic Stem Cell Research? It's About Human Engineering, Not Ending Disease


Latest News from our Front Page

Holocaust, Hate Speech and Were the Germans so Stupid?
2015-02-28 20:31
Description form YouTube: This is an updated version of the video which was taken down by YouTube following a spurious copyright-infringement claim. It addresses issues regarding claims that Zyklon B in liquid form gives off fumes at temperatures below 0º C. As the world approaches the brink of a new Middle East crisis this time involving Syria, clearly at the behind-the-scenes ...
The Jewish Roots of Leonard Nimoy and What the ‘Live Long and Prosper’ Hand Symbol Really Means
2015-02-28 0:20
Leonard Nimoy first saw what became the famous Vulcan salute, “live long and prosper,” as a child, long before “Star Trek” even existed. The placement of the hands comes from a childhood memory, of an Orthodox Jewish synagogue service in Boston. The man who would play Spock saw the gesture as part of a blessing, and it never left him. “Something ...
Baby born still INSIDE his amniotic sac is hailed a ‘medical miracle’ by doctors [Video]
2015-02-27 22:46
What an incredible miracle… Not only was the little boy three months early – he was born inside his amniotic sac. I’ve never heard of this happening before. If you look at the picture, you can see him clearly with his little arms and legs curled up. He was still being given oxygen by his mom until the sac was ...
California Infant Dies after 8 Vaccines, Family Gets Him Back from Hospital Cremated
2015-02-27 21:55
Parents in California are distraught after losing their infant son after being vaccinated. He died in his sleep and was taken to the hospital already deceased. Hospital staff ruled his death as sudden infant death syndrome. The couple was told an autopsy was required to be performed on their son. After returning home, waiting to get an update, they never received ...
DNA: Data-storage for eternity
2015-02-27 20:57
How can we preserve our knowledge today for the next millennia? ETH researchers have found a way to store information in the form of DNA, preserving it for nearly an eternity. Scrolls thousands of years old provide us with a glimpse into long-forgotten cultures and the knowledge of our ancestors. In this digital era, in contrast, a large part of our ...
More News »