Do you really want to live forever?
2009 07 21

By Dr Mark Porter | TimesOnline.co.uk

There are developments that could (and probably will) lead to humans being able to live forever. But is it desirable?

A naturally occurring substance found in the soil of Easter Island, in the southeastern Pacific Ocean, is the latest discovery in Man’s ongoing quest for the elixir of youth. Rapamycin may extend the life expectancy of laboratory mice but, despite the recent hype, there is no evidence that it will do the same for us. It will, however, give researchers a better understanding of why we age — a process that they hope one day to be able to slow or stop. And there is growing optimism that their work is more science fact rather than science fiction.



Ageing is not inevitable. The sea anemone is an example of a species that never appears to age, and there is tremendous variation in life expectancy among animals. Most voles won’t make their first birthday, while a giant tortoise can live to well over 150.

The average life expectancy of a British human being lies almost exactly halfway between these two extremes, with most of us alive today expected to make it well into our eighties — a figure that has risen over the past century as a result of better nutrition, living conditions and healthcare. And this increasing longevity has also been associated with better quality of life. The latest evidence suggests that people who die at 90 spend roughly the same amount of time in hospital as those who die in their seventies, and only twice as long as those who die in their mid-forties.

But to make further inroads into extending our life expectancy we need to do more than negate hazards such as disease and accidents. We need to slow the ticking of our genetic clocks.

At the moment even the best cared for human being is unlikely to make it much beyond 120 because the body’s natural repairing processes grind to a halt and whole systems start to fail.

Our tissues don’t have a pre-programmed best-before date, but their inbuilt repair processes do, and it is these that largely determine the rate at which we age. Our basic software — DNA — is particularly sensitive to damage, with an attack rate that has been estimated at 10,000 damaging hits per cell, per day. Multiply this figure by the one hundred thousand billion or so cells in the average human body and you get some idea of the challenge faced by our repair systems. Suffice to say there is a bit more to them than healing cuts and grazes.

The onslaught comes from all directions — everything from sunlight to tobacco smoke — but the main villain is oxygen. We need it to create energy, but in the same way that it turns a newspaper yellow and iron rusty, it also eats away at our structure.

Constant repair uses up a lot of energy and can weaken the processes involved, as demonstrated by what happens when our chromosomes divide during cell replication.

To prevent damage to the DNA during cell renewal, chromosomes contain special structures called telomeres that protect the delicate strands as they unravel and reform. Think of them as the plastic caps on the ends of your shoelaces. The more times the DNA is “tied” and “untied”, the shorter the telomeres become until, perhaps after 100 renewals, the telomeres disappear altogether and the DNA starts to fray. And that is the beginning of the end for the cell.

So, one way to think of our life expectancy is to consider that we are only as old as our telomeres. The longer they are, the longer you are likely to live, and vice versa, as children with the rare condition progeria discover to their cost. A child with progeria is born with unusually short telomeres (roughly the same as those normally found in a 70 or 80-year-old) and ages at an incredible rate, with few living beyond their early teens.

Unfortunately, human adult cells don’t have any way of repairing damaged telomeres, so cell death is inevitable, but a repair enzyme — telomerase — does exist in sperm and the female egg. Researchers in America have managed to insert the genes that produce it into adult skin cells and two years later they were still happily dividing without their telomeres getting any shorter.

Producing a potentially immortal skin cell in a Petri dish in a lab is a long way from significantly extending human life expectancy, but it is a step in the right direction and the solution is likely to come from genetic engineering rather than from some as-yet-undiscovered natural panacea. And it is not so much if, as when.

Any such breakthrough is going to happen too late to help most of us — something that I am actually quite pleased about, as I have no desire to live for ever. I just want to enjoy a full and active life before dropping dead quite unexpectedly some time in my eighties.

Article from: TimesOnline.co.uk




Longevity & The Holy Grail Promo

Aubrey de Grey, Artificial Intelligence, Singularity, Longevity and the Holy Grail

Red Ice Creations Radio - Michael Tsarion - The Post Human World

Sonia Barrett - Immortality and the Quest for Eternal Life

Doctors Baffled, Intrigued by Girl Who Doesn't Age



Related Articles
Bring on the nanobots, and we will live long and prosper
Army Seeks Fountain of Youth in Body's Powerhouses
Human DNA - The Sacred Science of Dying - Video (5 parts)
Should we trust DNA?
Aubrey de Grey, Artificial Intelligence, Singularity, Longevity and the Holy Grail
Breaking the age barrier
15 tips on how to live to 100


Latest News from our Front Page

6,000-Year-Old Temple with Possible Sacrificial Altars Discovered
2014 10 21
A 6,000-year-old temple holding humanlike figurines and sacrificed animal remains has been discovered within a massive prehistoric settlement in Ukraine. Built before writing was invented, the temple is about 60 by 20 meters (197 by 66 feet) in size. It was a "two-story building made of wood and clay surrounded by a galleried courtyard," the upper floor divided into five ...
What happened to Journalist Serena Shim? Assassinated? Find out what happened to Serena, Press TV director calls on Turkey
2014 10 21
Press TV news director Hamid Reza Emadi says the “suspicious death,” of the news channel’s correspondent in Turkey is a tragedy for “anyone who wants to get the truth.” Emadi made the remarks in an interview with Press TV on Sunday following Serena Shim’s death across the border from Syria’s Kurdish city of Kobani, where the ISIL terrorists and Kurdish fighters ...
Ancient Roman Nanotechnology Inspires Next-Generation Holograms for Information Storage
2014 10 21
The Lycurgus Cup, as it is known due to its depiction of a scene involving King Lycurgus of Thrace, is a 1,600-year-old jade green Roman chalice that changes colour depending on the direction of the light upon it. It baffled scientists ever since the glass chalice was acquired by the British Museum in the 1950s, as they could not work ...
Rapid Geomagnetic Reversal Possibility: Confirmed
2014 10 21
From the video: "The scientists who conducted the study are still unsure why the magnetic field is weakening, but one likely reason is the Earth’s magnetic poles are getting ready to flip, said Rune Floberghagen, the ESA’s Swarm mission manager. In fact, the data suggest magnetic north is moving toward Siberia." Tune into Red Ice Radio: Ben Davidson - Suspicious0bservers: Space Weather ...
Georgia Guide Stone 2014 cube stone removal
2014 10 21
From: Youtube: Was it all just a gag? it seems the cube stone just happens to be made out of the same Elberton granite that the rest of this morbid monument is made from.
More News »