Mice Inherit the Fears of Their Fathers
2013 11 21
By Virginia Hughes | Phenomena
There’s no question that trauma gets handed down from one generation to the next.
In one highly publicized example, researchers in New York studied several dozen women who were pregnant on September 11, 2001, and had been in the vicinity of the terrorist attacks. Some of these women developed post-traumatic stress disorder (PTSD), and this group shows lower levels of the stress hormone cortisol in their saliva than do those who did not develop PTSD. But here’s the rub: At 9 months old, the babies of the women with PTSD have significantly lower cortisol levels than babies of healthy mothers.
In earlier work, the same researchers had reported low cortisol levels in adult children of Holocaust survivors with PTSD. And in yet another study, Kerry Ressler’s group at Emory University showed that the so-called “startle response” to a sudden stimulus — a marker of anxiety — is more pronounced in kids whose mothers were physically abused as children then in those whose mothers were not abused. I could go on.
But how, exactly, does a parent’s stress leave such a deep impression on its progeny?
Part of it is nurture. A parent’s sadness and stress naturally affects how they interact with other people, including their children. The Holocaust study, in fact, found that the survivors with PTSD tended to emotionally abuse or neglect their children. And we know from some remarkable experiments in rats that parental care affects the offspring’s genes: Rat pups that get a lot of licking and grooming from their mothers show distinct changes in their epigenome, the chemical markers that attach to DNA and can turn genes on and off. Neglected pups, in contrast, don’t show these epigenetic tweaks.
Now a fascinating new study reveals that it’s not just nurture. Traumatic experiences can actually work themselves into the germ line. When a male mouse becomes afraid of a specific smell, this fear is somehow transmitted into his sperm, the study found. His pups will also be afraid of the odor, and will pass that fear down to their pups.
“Parents transfer information to their offspring, and they do so even before the offspring are conceived,” said Brian Dias, a postdoctoral fellow in Ressler’s lab, at an engaging talk about this unpublished data on Tuesday at the Society for Neuroscience meeting in San Diego.
And why, evolutionarily, would a parent pass down such specific information? “So that when the offspring, or descending generations, encounter that environment later in life, they’ll know how to behave appropriately,” Dias said.
The researchers made the mice afraid of certain odors by pairing them with a mild shock to the foot. In a study published a few years ago, Ressler had shown that this type of fear learning is specific: Mice trained to fear one particular smell show an increased startle to that odor but not others. What’s more, this fear learning changes the organization of neurons in the animal’s nose, leading to more cells that are sensitive to that particular smell.
Dias trained mice to fear acetophenone — which, according to this chemist, smells “like orange blossom with a bit of artificial cherry” — over three days, then waited 10 days and allowed the animals to mate. The offspring (known as the F1 generation) show an increased startle to acetophenone (with no shock) even though they have never encountered the smell before. And their reaction is specific: They do not startle to a different odor, propanol (which smells like alcohol). What’s more, the researchers found the same thing in the F1 generation’s offspring (known as F2).
Read the full article at: phenomena.nationalgeographic.com
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