Lab-made kidneys raise hopes for dialysis patients
By Sharon Begley | Reuters
Scientists have discovered yet another way to make a kidney - at least for a rat - that does everything a natural one does, researchers reported on Sunday, a step toward savings thousands of lives and making organ donations obsolete.
The latest lab-made kidney sets up a horse race in the booming field of regenerative medicine, which aims to produce replacement organs and other body parts.
The collagen scaffolding of a kidney, left behind after removing the cells, is pictured in this undated handout photo obtained by Reuters April 12, 2013
Several labs are competing to develop the most efficient method to produce the most functional organs through such futuristic techniques as 3D printing, which has already yielded a lab-made kidney that works in lab rodents, or through a "bioreactor" that slowly infuses cells onto the rudimentary scaffold of a kidney, as in the latest study.
The goal of both approaches is to help people with kidney failure. In the United States, 100,000 people with end-stage renal disease are on waiting lists for a donor kidney, but 5,000 to 10,000 die each year before they reach the top of the transplant list.
Even the 18,000 U.S. patients each year who do get a kidney transplant are not out of the woods. In about 40 percent the organ fails within 10 years, often fatally.
If what succeeded in rats "can be scaled to human-sized grafts," then patients waiting for donor kidneys "could theoretically receive new organs derived from their own cells," said Dr. Harald Ott, of the Center for Regenerative Medicine at Massachusetts General Hospital in Boston. He led the research reported on Sunday in the online edition of Nature Medicine.
That would minimize the risk of rejection and make more organs available.
Ott’s group used an actual kidney as its raw material, but competing labs are using 3D bioprinters to create the starting material, the scaffold or framework of the organ.
"With a 3D bioprinter, you wouldn’t require donor organs," said Dr. Anthony Atala, director of the Institute for Regenerative Medicine at Wake Forest School of Medicine in North Carolina and a pioneer in that technology.
"The printer also lets you be very precise in where the cells go" on and in the scaffold. But he hailed the Massachusetts General Hospital work as "one more study that confirms these technologies are possible."
Read the full article at: reuters.com
Man dies after doc takes lunch during kidney op
Surgeon: Remove Kidneys for Transplant Before Donor’s Death
Anthony Atala: Printing a human kidney
Chinese teenager sells his kidney so he can buy an iPad2
Parole condition: US inmate must give kidney to sister to have life sentence lifted
Complications (Black Market Kidney Transplants)
Ethics of uterus transplants debated
Russian research project offers ’immortality’ to billionaires - by transplanting their brains into robot bodies
Doctors Transplant Vein Grown from Patient’s Own Cells
3D Printing To Help Creation of Artificial Human Organs
A 3D Printer That Generates Human Embryonic Stem Cells
Latest News from our Front Page
Pressure from the United Patriots Front Stops Mosque Plan
Pressure from the United Patriots Front appears to have killed off a mosque development in Narre Warren North.
The City of Casey council now looks likely to withhold planning approval for the development in a special meeting set for Tuesday night.
A council report, to be considered by councillors on Tuesday, recommends that the approval be blocked.
The mosque opponents’ cause has been helped by councillor ...
Police face questions over the influence of the Freemasons
South Yorkshire Police today face questions over whether powerful 'secret society' the Freemasons held sway over the force at the time of Hillsborough.
Families of victims say that officers who were Masons were promoted into powerful positions despite being ill-equipped, including match commander David Duckenfield.
Duckenfield told the fresh inquests he had been a Freemason since 1975 and became head of his ...
England Bans its Own Flag to Avoid Offending Muslims
St. George's Cross "racist" towards immigrants
Government officials said their city was ‘too multicultural’ to celebrate St George’s Day, England’s version of the 4th of July.
The council said that displaying the English flag may have been seen as “racist” towards immigrants.
Half of Western European men descended from one Bronze Age ‘king’
Half of Western European men are descended from one Bronze Age ‘king’ who sired a dynasty of elite nobles which spread throughout Europe, a new study has shown.
The monarch, who lived around 4,000 years ago, is likely to have been one of the earliest chieftains to take power in the continent.
He was part of a new order which emerged in ...
"Local Residents" Are Filmed Stealing Dozens of Bottles of Water at London Marathon Stop
Editor's Comment: "Local" residents? Why bother blurring their faces? We know who they are.
London marathon runners were robbed of dozens of bottled waters when thieves raided a refreshment area armed with trolleys during today's race.
Nearby residents - including parents with children - were captured on camera piling up crates of free water handed out by volunteers during the 26-mile event.
|More News » |