Deleting Obesity Gene in Mice Eliminates Obesity, Might Work for Humans
From: Science Daily
Researchers have discovered that deleting a specific gene in mice prevents them from becoming obese even on a high fat diet, a finding they believe may be replicated in humans.
"When fed a diet that induces obesity these mice dont get fat," said Prof. James McManaman, Ph.D., lead author of the study and vice-chairman of research for Obstetrics and Gynecology at the University of Colorado School of Medicine. "It may be possible to duplicate this in humans using existing technology that targets this specific gene."
The two-year study, funded by the National Institutes of Health and the U.S. Department of Agriculture, was published last month in the Journal of Lipid Research.
The research team created a strain of mice without the Plin2 gene which produces a protein that regulates fat storage and metabolism. They immediately found that the mice were resistant to obesity.
Usually, mice fed a high fat diet will eat voraciously, yet these showed an unusual restraint. Not only did they eat less, they were more active.
Their fat cells were also 20 percent smaller than typical mice and did not show the kind of inflammation usually associated with obesity, the study said. Obesity-associated fatty liver disease, common in obese humans and rodents, was absent in the mice without the Plin2 gene.
"The mice were healthier," McManaman said. "They had lower triglyceride levels, they were more insulin-sensitive, they had no incidents of fatty liver disease and there was less inflammation in the fat cells."
Read the full article at: sciencedaily.com
Lab rats acquire sixth sense
Circadian clock linked to obesity, diabetes and heart attacks
Study Links Fructose with Overeating, Obesity
Scientists find "master switch" gene for obesity
U.S. Kids Consuming Fewer Calories, Report Finds
Diet Soda: Sweet Words and Sour Reality
The Caveman Diet: Grain Free, Disease Free
Sugar makes you stupid: Study shows high-fructose diet sabotages learning, memory
Latest News from our Front Page
Better Identification of Viking Corpses Reveals: Half of the Warriors Were Female
Shieldmaidens are not a myth! A recent archaeological discovery has shattered the stereotype of exclusively male Viking warriors sailing out to war while their long-suffering wives wait at home with baby Vikings. (We knew it! We always knew it.) Plus, some other findings are challenging that whole ârape and pillageâ thing, too.
Researchers at the University of Western Australia decided ...
Off Your Knees, Germany! Ernst Zundel 1983 - 2003
For more information on the holocaust, how the war was forced upon Germany, and the REAL victims of the second world war see:
IRS Drops Attack For Six Years â No Evidence of Jurisdiction
A big congrats to a friend Iâve been working with for several years, he stood up to the predators commonly called the âIRSâ and they dropped their attack. Thanks also for providing me with the proof below.
The criminals called the âIRSâ initiated an attack claiming my friend was required to file six tax returns, or explain how he made ...
Into Eternity - Finland's 100,000 Year Massive Underground Spent Nuclear Fuel Program
Into Eternity is a documentary about a deep geological repository for nuclear waste. The concept of long-term underground storage for radioactive waste has been explored since the 1950s. The inner part of the Russian doll-like storage canisters is to be composed of copper. Hence in the case of Onkalo it is tightly linked to experiments on copper corrosion in running ...
SPLC Accuses Oath Keepers of Inciting âArmed Confrontationâ Over Sugar Pine Mine
The Southern Poverty Law Center has accused Oath Keepers of inciting an armed confrontation with BLM authorities over the Sugar Pine Mine dispute in Oregon, despite the fact that the organization has explicitly stated that it is not promoting armed confrontation with the feds.
In an article provocatively posted on the organizationâs âHatewatchâ section entitled Oath Keepers Descend Upon Oregon with ...
|More News » |