Deleting Obesity Gene in Mice Eliminates Obesity, Might Work for Humans
2013 03 05
From: Science Daily
Researchers have discovered that deleting a specific gene in mice prevents them from becoming obese even on a high fat diet, a finding they believe may be replicated in humans.
"When fed a diet that induces obesity these mice don’t get fat," said Prof. James McManaman, Ph.D., lead author of the study and vice-chairman of research for Obstetrics and Gynecology at the University of Colorado School of Medicine. "It may be possible to duplicate this in humans using existing technology that targets this specific gene."
The two-year study, funded by the National Institutes of Health and the U.S. Department of Agriculture, was published last month in the Journal of Lipid Research.
The research team created a strain of mice without the Plin2 gene which produces a protein that regulates fat storage and metabolism. They immediately found that the mice were resistant to obesity.
Usually, mice fed a high fat diet will eat voraciously, yet these showed an unusual restraint. Not only did they eat less, they were more active.
Their fat cells were also 20 percent smaller than typical mice and did not show the kind of inflammation usually associated with obesity, the study said. Obesity-associated fatty liver disease, common in obese humans and rodents, was absent in the mice without the Plin2 gene.
"The mice were healthier," McManaman said. "They had lower triglyceride levels, they were more insulin-sensitive, they had no incidents of fatty liver disease and there was less inflammation in the fat cells."
Read the full article at: sciencedaily.com
Lab rats ’acquire sixth sense’
Circadian clock linked to obesity, diabetes and heart attacks
Study Links Fructose with Overeating, Obesity
Scientists find "master switch" gene for obesity
U.S. Kids Consuming Fewer Calories, Report Finds
Diet Soda: Sweet Words and Sour Reality
The Caveman Diet: Grain Free, Disease Free
Sugar makes you stupid: Study shows high-fructose diet sabotages learning, memory
Latest News from our Front Page
A Look at Theories About Elongated Skulls in Ancient Peru, Europe, Egypt
2014 07 31
Elongated skulls have been found in ancient burial grounds around the world. Many are the result of a practice of intentionally deforming the skull with binding applied during the early years of a child’s life. Some may be explained by natural deformity. Yet enough mystery is left in relation to some of the skulls for various theories to arise.
Could the ...
EU on high alert as Germany accepts Ebola patients
2014 07 30
A German hospital has agreed to treat Ebola patients amid widespread fears of a possible outbreak of the deadly disease in Europe. Over 670 people have already been killed by the disease in West Africa with doctors struggling to control the epidemic.
A German hospital in Hamburg agreed to accept patients following a request from the World Health Organization (WHO), Deutsche ...
Bolivia declares Israel terrorist regime
2014 07 30
Bolivia has declared Israel a “terrorist state” and revoked a visa exemption agreement with Tel Aviv in protest at the ongoing Israeli attacks on the besieged Gaza Strip.
The move "means, in other words, we are declaring (Israel) a terrorist state," President Evo Morales said during talks with a group of educators in the city of Cochabamba ...
Pagan Traditions: Mysteries of medieval graffiti in England’s churches
2014 07 30
Medieval graffiti of straw kings, pentagrams, crosses, ships and "demon traps" have been offering a tantalising glimpse into England’s past. What do the pictures reveal about life in the Middle Ages?
A project to record the graffiti, which began in Norfolk, has now been rolled out to other areas and is gradually spreading across England.
Armed with just a torch and a ...
More Gigantic Holes Appear in Siberia’s ’End of the World’
2014 07 30
Is it the end of the world in Siberia’s ’End of the World’?
Scientists suspect not, but they’re still investigating the strange and alarming holes that are swallowing up the Siberian north.
This week two new holes have been discovered, and with similar characteristics as the first reported hole: a very deep shaft with smooth sides, debris surrounding the rim, and water ...
|More News » |