Deleting Obesity Gene in Mice Eliminates Obesity, Might Work for Humans
From: Science Daily
Researchers have discovered that deleting a specific gene in mice prevents them from becoming obese even on a high fat diet, a finding they believe may be replicated in humans.
"When fed a diet that induces obesity these mice don’t get fat," said Prof. James McManaman, Ph.D., lead author of the study and vice-chairman of research for Obstetrics and Gynecology at the University of Colorado School of Medicine. "It may be possible to duplicate this in humans using existing technology that targets this specific gene."
The two-year study, funded by the National Institutes of Health and the U.S. Department of Agriculture, was published last month in the Journal of Lipid Research.
The research team created a strain of mice without the Plin2 gene which produces a protein that regulates fat storage and metabolism. They immediately found that the mice were resistant to obesity.
Usually, mice fed a high fat diet will eat voraciously, yet these showed an unusual restraint. Not only did they eat less, they were more active.
Their fat cells were also 20 percent smaller than typical mice and did not show the kind of inflammation usually associated with obesity, the study said. Obesity-associated fatty liver disease, common in obese humans and rodents, was absent in the mice without the Plin2 gene.
"The mice were healthier," McManaman said. "They had lower triglyceride levels, they were more insulin-sensitive, they had no incidents of fatty liver disease and there was less inflammation in the fat cells."
Read the full article at: sciencedaily.com
Lab rats ’acquire sixth sense’
Circadian clock linked to obesity, diabetes and heart attacks
Study Links Fructose with Overeating, Obesity
Scientists find "master switch" gene for obesity
U.S. Kids Consuming Fewer Calories, Report Finds
Diet Soda: Sweet Words and Sour Reality
The Caveman Diet: Grain Free, Disease Free
Sugar makes you stupid: Study shows high-fructose diet sabotages learning, memory
Latest News from our Front Page
The Josh Duggar Incident Reveals The Tactics And Hypocrisy of SJWs
Last week, In Touch Weekly broke the news that Josh Duggar, eldest son of Jim Bob and Michelle Duggar from TLCâ€™s 19 Kids and Counting, had molested five under-aged girls in 2002 and 2003. Josh, who was 14 at the time, was accused of fondling his victims, touching their breasts and genitals while they slept.
A police report was released shortly ...
15 More Men of South Asian Descent Charged With Child Sex Offences
Police in Keighley, West Yorkshire have charged 14 men and a 16-year-old boy with sex offences including the rape of a girl under the age of 16. The offences relate primarily to one female victim, with one allegation involving a second who was also under 16 at the time.
The offences are alleged to have occurred between 2011 and 2012. In ...
Anti-Semitic fliers left on Chevy Chase driveways
Five streets in Chevy Chase, Md., were papered with anti-Semitic fliers on Wednesday morning.
Montgomery County police are looking for the person or people who left the hate-filled leaflets on almost every driveway on the streets.
â€śThis is very disturbing. My community is definitely disturbed,â€ť said Jean Sperling, the village manager of Martinâ€™s Additions, the community where the fliers were found. Sperling ...
German court says ex-SS officer unfit for trial
Prosecutors in the northern German city of Hamburg have dropped their probe into a 93-year-old former Nazi SS officer. Gerhard Sommer, who suffers from dementia, allegedly took part in a World War II massacre in Italy.
Gerhard Sommer, a former company commander of a mechanized infantry division, had been accused of participating in the mass murder of 560 civilians by Nazi ...
The Age of Disinformation
I have been a professional meteorologist for 36 years. Since my debut on television in 1979, I have been an eyewitness to the many changes in technology, society, and how we communicate. I am one who embraces change, and celebrates the higher quality of life we enjoy now thanks to this progress.
But, at the same time, I realize the instant ...
|More News » |