Brain Cells Made from Urine
By Monya Baker | ScientificAmerican.com
Human excreta could be a powerful source of cells to study disease, bypassing some of the problems of using stem cells, such as the risk of developing tumors and difficulties in obtaining blood samples from children.
Some of the waste that humans flush away every day could become a powerful source of brain cells to study disease, and may even one day be used in therapies for neurodegenerative diseases. Scientists have found a relatively straightforward way to persuade the cells discarded in human urine to turn into valuable neurons.
The technique, described online in a study in Nature Methods this week, does not involve embryonic stem cells. These come with serious drawbacks when transplanted, such as the risk of developing tumors. Instead, the method uses ordinary cells present in urine, and transforms them into neural progenitor cells — the precursors of brain cells. These precursor cells could help researchers to produce cells tailored to individuals more quickly and from more patients than current methods.
Getting neurons from cells discarded in urine, may one day help develop therapies for neurodegenerative diseases like Parkinson’s disease.
Researchers routinely reprogram cultured skin and blood cells into induced pluripotent stem (iPS) cells, which can go on to form any cell in the body. But urine is a much more accessible source.
Stem-cell biologist Duanqing Pei and his colleagues at China’s Guangzhou Institutes of Biomedicine and Health, part of the Chinese Academy of Sciences, had previously shown that kidney epithelial cells in urine could be reprogrammed into iPS cells.
However, in that study the team used retroviruses to insert pluripotency genes into cells — a common technique in cell reprogramming. This alters the genetic make-up of cells and can make them less predictable, so in this study, Pei and his colleagues introduced the genes using vectors which did not integrate in the cellular genome.
One of their experiments produced round colonies of reprogrammed cells from urine that resembled pluripotent stem cells after only 12 days — about half the time usually required to produce iPS cells. When cultured further, the colonies took on the rosette shape common to neural stem cells.
Pei and his colleagues transferred the cells to a growth medium used for neurons, and found that these reprogrammed cells went on to form functional neurons in the lab.
When the team repeated the experiment and transplanted the cells into newborn rat brains, the cells did not form tumors. Instead, when the brains were examined four weeks later, the cells had taken on the shape and molecular markers of neurons.
Read the full article at: scientificamerican.com
Latest News from our Front Page
Pro-Israel bias: BBC admits editorial breach in interview with Israeli defense chief
The BBC has reached a â€śprovisional findingâ€ť to uphold complaints made by Palestinian activists that the broadcaster breached its editorial guidelines in a â€śsoftâ€ť interview with the Israeli defense minister.
Complaints focused on BBC journalist Sarah Montagueâ€™s alleged failure to challenge controversial claims made by Israeli Defense Minister Moshe Yaâ€™alon.
Journalist Amena Saleem, who works with the Palestine Solidarity Campaign (PSC), wrote ...
41% of Americans Support Criminalizing "Hate Speech"
The following are from a recent poll about what some are calling on for "hate speech"
1. Support for Hate Crimes Legislation
Do you support or oppose the federal law that requires increased penalties for hate crimes committed on the basis of the actual or perceived race, color, religion, national origin, ethnicity, or gender of any person?
2. Support for Expanding Hate Crimes
FBI Admits No Major Cases Cracked with Patriot Act Snooping Powers
FBI agents canâ€™t point to any major terrorism cases theyâ€™ve cracked thanks to the key snooping powers in the Patriot Act, the Justice Departmentâ€™s inspector general said in a report Thursday that could complicate efforts to keep key parts of the law operating.
Inspector General Michael E. Horowitz said that between 2004 and 2009, the FBI tripled its use of bulk ...
Sweetener Stevia Was Once Hailed As An Anti-Fertility Agent for Population Reduction
Maybe it's not so sweet now... If you've thought stevia, the natural alternative to sugar and artificial sweetners with aspartame, et al., is too good to be true, there may be a catch. Check out this textbook written in 1970 by Paul and Anne Ehrlich, the precursor to the textbook Ecoscience they wrote with Obama Science Czar John P. Holdren ...
TPP Aproved: Senate Republicans Give Obama New Powers - Details Remain 'Classified'
President Obama won a big victory for his trade agenda Friday with the Senateâ€™s approval of fast-track legislation that could make it easier for him to complete a wide-ranging trade deal that would include 11 Pacific Rim nations.
A coalition of 48 Senate Republicans and 14 Democrats voted for Trade Promotion Authority late Friday, sending the legislation to a difficult fight ...
|More News » |