Placebo’s Effect May Depend on Your Genes
2012 11 01
Your response to placebos, or dummy medicine, may depend on your genes, according to a new study. People with a gene variant that codes for higher levels of the brain chemical dopamine respond better to placebos than those with the low-dopamine version. The findings, reported online Oct. 23 in the journal PLoS One, could help researchers design medical studies that distinguish the placebo response from the underlying effect of a medicine — the real aim of drug trials.
“This is a possible way to discern who is going to be a placebo responder or nonresponder in a clinical trial,” said study co-author Kathryn Hall of Beth Israel Deaconess Medical Center in Brookline, Mass.
People report feeling better after receiving a placebo, such as a sugar pill or fake treatment, for conditions ranging from chronic pain to Parkinson’s disease. But only some patients respond strongly, and there’s no way to predict who will improve on a placebo. A few studies have provided clues. Differences in versions of the catechol-O-methyltransferase (COMT) gene, which determines levels of dopamine in the brain’s prefrontal cortex, are linked to differences in reward-seeking and pain perception. People with the high-dopamine version, or allele, of the COMT gene feel pain more acutely and seek rewards more strongly than those who have the low-dopamine copy.
That led the researchers to wonder whether the gene modulates placebo response. To find out, Hall and her colleagues analyzed DNA from 104 patients with irritable bowel syndrome who were randomized to one of three groups: One was told they were on the waiting list for treatment, another received a placebo in the form of seemingly real, curt acupuncture, and the third group received fake acupuncture from a caring, warm practitioner who looked patients in the eye, asked about their progress, and even touched them lightly, Hall told LiveScience.
Patients with the high-dopamine version of the gene felt slightly better after seeing the curt, all-business health-care provider that gave placebo acupuncture. But they were six times as likely to say their symptoms improved with a caring practitioner as those with the low-dopamine gene, who didn’t improve much in any group. The findings suggest that medical studies called clinical trials could identify treatment versus placebo effect by grouping patients by gene variant, Hall said. Knowing up front the level of placebo effect for a clinical trial could reduce the cost of the trial significantly by using fewer participants, for instance, she said.
People with the high-dopamine allele of the gene may do well on the placebo with the nurturing treatment because they are generally more attuned to their environments, said University of Michigan psychiatrist Jon-Kar Zubieta, who was not involved in the study.
“It speaks about an interaction between the environment and the gene,” Zubieta said. “It’s very possible that individuals with this allele are more able to process those positive environmental cues.”
Article from: deskarati.com
Tune into Red Ice Radio:
Bruce Lipton - The Biology of Belief
David Crowe - Rethinking AIDS
Anthony Peake & Tom Campbell - Consciousness Creates Reality
Michael Sharp - Consciousness & The Ascension Process
Lloyd Pye - Human Design & Properties of Annunaki Genes
Nick Begich - Hour 1 - Controlling the Human Mind
Dr David Hamilton: Placcebo Effect & Quantum Healing
Dr David Hamilton ’The Science Of Belief’
Biology of Belief - by Bruce Lipton (Documentary)
Marmosets can meditate (and are immune to the placebo effect)
Placebo Effect’s Neural Activity Photographed for First Time
The Placebo Effect - The Triumph of Mind over Body
Latest News from our Front Page
Why Can’t We Publish Addresses Of New York Times Reporters?
2014 11 28
New York Times reporters Julie Bosman and Campbell Robertson published the address of Darren Wilson in the New York Times so here are their addresses.
GotNews.com strenuously objects to publishing the addresses of individuals who are being targeted with death threats.
GotNews.com published the address of Ebola patient Nina Pham so that people could avoid going to her Dallas apartment.
But it would ...
Terrorists? Interview with Varg Vikernes and Marie Cachet
2014 11 28
Marie Cachet and Varg Vikernes are what we call commonly ordinary people. However, for motives meanly political, the Ministry of the Interior decided to abuse its power to damage them ; "there is nothing more annoying than a low man placed in high position." (Roman saying) Today, Varg risks the eviction of the French territory without valid ground. Three very ...
The Coudenhove-Kalergi Plan - The Genocide Of The People Of Europe
2014 11 28
Mass immigration is a phenomenon, the causes of which are still cleverly concealed by the system, and the multicultural propaganda is trying to falsely portray it as inevitable. With this article we intend to prove once and for all, that this is not a spontaneous phenomenon. What they want to present as an inevitable outcome of modern life, is actually ...
Starbucks Supports Pro-GMO Company
2014 11 26
Another reason why you should not go to Starbucks.
Starbucks has an image of being a socially responsible, environmentally friendly company (Really?). In 2013, 95 percent of their coffee was ethically sourced, and their goal is to reach 100 percent by 2015.1
Other goals include reducing water consumption by 25 percent in their company-operated stores by 20152 and mobilizing their employees and ...
Group Polarization and the Fad of Ethno-masochism
2014 11 26
From "Group polarization: A critical review and meta-analysis". Journal of Personality and Social Psychology. 6 50 (6): 1141--1151
The psychology of White self hatred. Political correctness IS a mental disorder.
Group polarization: A critical review and meta-analysis.
Isenberg, Daniel J. the paper
Harvard Professor Noel Ignatiev talks about how to end the White race
The History of Political Correctness
The Narrative: The origins of Political ...
|More News » |