Placebo’s Effect May Depend on Your Genes
2012 11 01
Your response to placebos, or dummy medicine, may depend on your genes, according to a new study. People with a gene variant that codes for higher levels of the brain chemical dopamine respond better to placebos than those with the low-dopamine version. The findings, reported online Oct. 23 in the journal PLoS One, could help researchers design medical studies that distinguish the placebo response from the underlying effect of a medicine — the real aim of drug trials.
“This is a possible way to discern who is going to be a placebo responder or nonresponder in a clinical trial,” said study co-author Kathryn Hall of Beth Israel Deaconess Medical Center in Brookline, Mass.
People report feeling better after receiving a placebo, such as a sugar pill or fake treatment, for conditions ranging from chronic pain to Parkinson’s disease. But only some patients respond strongly, and there’s no way to predict who will improve on a placebo. A few studies have provided clues. Differences in versions of the catechol-O-methyltransferase (COMT) gene, which determines levels of dopamine in the brain’s prefrontal cortex, are linked to differences in reward-seeking and pain perception. People with the high-dopamine version, or allele, of the COMT gene feel pain more acutely and seek rewards more strongly than those who have the low-dopamine copy.
That led the researchers to wonder whether the gene modulates placebo response. To find out, Hall and her colleagues analyzed DNA from 104 patients with irritable bowel syndrome who were randomized to one of three groups: One was told they were on the waiting list for treatment, another received a placebo in the form of seemingly real, curt acupuncture, and the third group received fake acupuncture from a caring, warm practitioner who looked patients in the eye, asked about their progress, and even touched them lightly, Hall told LiveScience.
Patients with the high-dopamine version of the gene felt slightly better after seeing the curt, all-business health-care provider that gave placebo acupuncture. But they were six times as likely to say their symptoms improved with a caring practitioner as those with the low-dopamine gene, who didn’t improve much in any group. The findings suggest that medical studies called clinical trials could identify treatment versus placebo effect by grouping patients by gene variant, Hall said. Knowing up front the level of placebo effect for a clinical trial could reduce the cost of the trial significantly by using fewer participants, for instance, she said.
People with the high-dopamine allele of the gene may do well on the placebo with the nurturing treatment because they are generally more attuned to their environments, said University of Michigan psychiatrist Jon-Kar Zubieta, who was not involved in the study.
“It speaks about an interaction between the environment and the gene,” Zubieta said. “It’s very possible that individuals with this allele are more able to process those positive environmental cues.”
Article from: deskarati.com
Tune into Red Ice Radio:
Bruce Lipton - The Biology of Belief
David Crowe - Rethinking AIDS
Anthony Peake & Tom Campbell - Consciousness Creates Reality
Michael Sharp - Consciousness & The Ascension Process
Lloyd Pye - Human Design & Properties of Annunaki Genes
Nick Begich - Hour 1 - Controlling the Human Mind
Dr David Hamilton: Placcebo Effect & Quantum Healing
Dr David Hamilton ’The Science Of Belief’
Biology of Belief - by Bruce Lipton (Documentary)
Marmosets can meditate (and are immune to the placebo effect)
Placebo Effect’s Neural Activity Photographed for First Time
The Placebo Effect - The Triumph of Mind over Body
Latest News from our Front Page
Ingraham to Zuckerberg: Time for Open Borders at Your Mansion
2014 09 19
Talk radio host Laura Ingraham re-iterated her challenge to debate Facebook co-founder and CEO Mark Zuckerberg and criticized him for securing his property while demanding the US allow illegal immigrants to remain in the country on Monday.
“In the end, borders work for these guys. Right, I would not want to be on [Facebook board member] Marc Andreesen’s household staff if ...
MasterCard tests Orwellian national ID card on Nigeria
2014 09 19
The march toward enslaving the world’s population by a handful of globalist statists and corporations continues, with the latest chapter unfolding, of all places, in Nigeria, compliments of MasterCard.
According to the website GovtSlaves.info, the credit card giant is rolling out a card in Africa’s most populous country that has the ability to retain all personal, health insurance, tax payment and ...
Doctor: Gov’t ‘Tight-Lipped’ on Respiratory Virus, May Be From Illegals
2014 09 19
Dr. Jane Orient, Executive Director of the Association of American Physicians and Surgeons, reported that the government has been “real tight-lipped” about the mysterious respiratory illness that has struck children in the United States, expressed concern that the illegal immigrant minors from Central America could be the source, and argued that the government should devote more resources to border security ...
Breaking—CDC whistleblower: “I’ve stopped lying”
2014 09 18
What more could anyone want in the way of evidence for an ongoing crime?
There is a video posted at the autism media channel/YouTube, and at Age of Autism: “William Thompson’s call to Congress.”
It is a recording of a telephone call between CDC whistleblower Thompson and Brian Hooker, PhD. No date is given.
Presumably, the call was recorded before August 27, when ...
Ebola patients buying survivors’ blood from black market, WHO warns
2014 09 18
As hospitals in nations hardest hit by Ebola struggle to keep up, desperate patients are turning to the black market to buy blood from survivors of the virus, the World Health Organization warned.
The deadliest Ebola outbreak in history has killed at least 2,400 people in Guinea, Liberia and Sierra Leone -- the countries most affected by the virus.
Thousands more are ...
|More News » |