Placebo’s Effect May Depend on Your Genes
2012-11-01 0:00

From: Deskarati





Your response to placebos, or dummy medicine, may depend on your genes, according to a new study. People with a gene variant that codes for higher levels of the brain chemical dopamine respond better to placebos than those with the low-dopamine version. The findings, reported online Oct. 23 in the journal PLoS One, could help researchers design medical studies that distinguish the placebo response from the underlying effect of a medicine — the real aim of drug trials.

“This is a possible way to discern who is going to be a placebo responder or nonresponder in a clinical trial,” said study co-author Kathryn Hall of Beth Israel Deaconess Medical Center in Brookline, Mass.

People report feeling better after receiving a placebo, such as a sugar pill or fake treatment, for conditions ranging from chronic pain to Parkinson’s disease. But only some patients respond strongly, and there’s no way to predict who will improve on a placebo. A few studies have provided clues. Differences in versions of the catechol-O-methyltransferase (COMT) gene, which determines levels of dopamine in the brain’s prefrontal cortex, are linked to differences in reward-seeking and pain perception. People with the high-dopamine version, or allele, of the COMT gene feel pain more acutely and seek rewards more strongly than those who have the low-dopamine copy.

That led the researchers to wonder whether the gene modulates placebo response. To find out, Hall and her colleagues analyzed DNA from 104 patients with irritable bowel syndrome who were randomized to one of three groups: One was told they were on the waiting list for treatment, another received a placebo in the form of seemingly real, curt acupuncture, and the third group received fake acupuncture from a caring, warm practitioner who looked patients in the eye, asked about their progress, and even touched them lightly, Hall told LiveScience.

Patients with the high-dopamine version of the gene felt slightly better after seeing the curt, all-business health-care provider that gave placebo acupuncture. But they were six times as likely to say their symptoms improved with a caring practitioner as those with the low-dopamine gene, who didn’t improve much in any group. The findings suggest that medical studies called clinical trials could identify treatment versus placebo effect by grouping patients by gene variant, Hall said. Knowing up front the level of placebo effect for a clinical trial could reduce the cost of the trial significantly by using fewer participants, for instance, she said.

People with the high-dopamine allele of the gene may do well on the placebo with the nurturing treatment because they are generally more attuned to their environments, said University of Michigan psychiatrist Jon-Kar Zubieta, who was not involved in the study.

“It speaks about an interaction between the environment and the gene,” Zubieta said. “It’s very possible that individuals with this allele are more able to process those positive environmental cues.”


Article from: deskarati.com











Tune into Red Ice Radio:

Bruce Lipton - The Biology of Belief

David Crowe - Rethinking AIDS

Anthony Peake & Tom Campbell - Consciousness Creates Reality

Michael Sharp - Consciousness & The Ascension Process

Lloyd Pye - Human Design & Properties of Annunaki Genes

Nick Begich - Hour 1 - Controlling the Human Mind







Related Articles
Dr David Hamilton: Placcebo Effect & Quantum Healing
Dr David Hamilton ’The Science Of Belief’
Biology of Belief - by Bruce Lipton (Documentary)
Marmosets can meditate (and are immune to the placebo effect)
Placebo Effect’s Neural Activity Photographed for First Time
The Placebo Effect - The Triumph of Mind over Body


Latest News from our Front Page

Thousands of migrants dumped on Britain as French wriggle out of border promise
2015-03-30 19:56
Thousands of migrants could be dumped on Britain’s doorstep if France tears up a historic border agreement, it was claimed last night. Officials have vowed to do “everything in their power” to wriggle out of a treaty moving the UK border to Calais. The besieged town’s mayor Natacha Bouchart is prepared to spark a major diplomatic row by opening the frontier ...
Richard III laid to rest at Leicester Cathedral
2015-03-30 18:36
King Richard III was today laid to rest at Leicester Cathedral - more than 500 years after his death in battle. The monarch, who reigned from 1483 to 1485, was the last of the Plantagenet dynasty. Actor Benedict Cumberbatch read a poem by Carol Ann Duffy during the service. Also in attendance was Robert Lindsay, who played Richard III in a version ...
Sweden - A new paradise for Romani beggars
2015-03-30 17:33
Thanks to the European Union and freedom of movement that follows with membership Sweden has been flooded with gypsies from Eastern Europe. Most member states have cracked down hard on the phenomenon of organized begging with legislation and forceful evictions so the Romani (colloquially known as Gypsies) who are engaged in this venture have moved their business to the country where ...
Increased tax subsidies for politically correct media
2015-03-29 22:08
On Dec 9 last year I translated a random snapshot of the biggest newspaper in Sweden. The headlines alone spoke for themselves. It was, simply put, an orgy of political correctness, obvious attempts at emotional manipulation and general national self-loathing. In other words, a typical Swedish newspaper on any given day. As more and more readers are waking up to the ...
When obeying the law and supporting yourself is racist
2015-03-29 22:56
There is a huge scandal in the municipality of Älmhult in Sweden. It has been revealed that there is a letter that may have been sent from the municipality offices to newly arrived immigrants informing them that the law applies to them and that they’re expected to eventually go off the dole and start pulling their own weight in society. In ...
More News »