New í100% accurateí test diagnoses schizophrenics simply by checking their gaze
2012-11-01 0:00

From: MailOnline

Scientists have developed an almost 100 per cent accurate test to detect schizophrenics - by checking their gaze.

Impaired eye movement has long been thought to be associated with schizophrenia.

Now a new study has reported a model of testing which demonstrated 98 per cent accuracy in distinguishing between those with and without schizophrenia.

Using ísimple viewing testsí, researchers at Aberdeen University explored the ability of eye movement tests to sort schizophrenics from healthy people.

People with schizophrenia showed well-documented deficits in the ability to track slow moving objects smoothly with their eyes.

Their eye movements tended to fall behind the moving object and then catch up again using rapid eye movements called ísaccadesí.

Schizophrenics also found it more difficult to maintain a steady gaze.

The study was led by Dr Philip Benson and Professor David St Clair and involved a range of eye tests where volunteers were asked to track slow moving objects slowly with their eyes (known as smooth pursuit), inspect a variety of everyday scenes (free viewing) and given instructions to keep a steady gaze on a single unmoving target (fixation tasks).

Their findings could speed up detection of the condition and they are now examining whether the tests can be used for earlier intervention in major mental illness.

Dr Benson said today: íIt has been known for over a hundred years that individuals with psychotic illnesses have a variety of eye movement abnormalities, but until our study, using a novel battery of tests, no one thought the abnormalities were sensitive enough to be used as potential clinical diagnostic biomarkers.

íIn smooth pursuit, people with schizophrenia have well-documented deficits in the ability to track slow moving objects smoothly with their eyes. Their eye movements tend to fall behind the moving object and then catch up with the moving object using rapid eye movements called saccades.

íIn the free-viewing test, whereas most individuals follow a typical pattern with their gaze as they scan the picture, those with schizophrenia follow an abnormal pattern and in the fixation task individuals with schizophrenia found it more difficult to maintain a steady gaze.í

This graphic shows schizophrenics and those without the condition track objects with their eyes differently.

Several methods were then used to model the data and the accuracy of each of the created algorithms was tested by using eye test data from another group of cases and controls. Combining all the data, one of the models achieved 98 per cent accuracy.

Professor St Clair added: íWe are keen to explore how best our findings can be developed for use in routine clinical practice.

íTypical neuropsychological assessments are time-consuming, expensive, and require highly trained individuals to administer. In comparison, these eye tests are simple, cheap, and take only minutes to conduct.

íThis means that a predictive model with such precision could potentially be incorporated in clinics and hospitals to aid physicians by augmenting traditional symptom-based diagnostic criteria.

íThe next thing we want to know is when the abnormalities are first detectable and can they be used as disease markers for early intervention studies in major mental illness?í

The study has been published in the November issue of the academic journal Biological Psychiatry.

The journalís editor Dr. John Krystal commented: íIt is encouraging to see the high sensitivity of this model for the diagnosis of schizophrenia. It will be interesting to see the extent to which this approach enables clinical investigators to distinguish people with schizophrenia from individuals with other psychiatric disorders.í

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