In a lab at MIT, a rat enters a T-shaped maze, hears a tone, and runs down the left arm towards a piece of chocolate. It’s a habit. The rat has done the same thing over so many days that once it hears the tone, it’ll run in the same direction even if there’s no chocolate to be found. Humans are driven by similar habits. Every morning, I hear my alarm go off, put some clothes on, and shamble into the kitchen to brew some coffee.
Habits, by their very nature, seem permanent, stable, automatic. But they are not, and the MIT rat tells us why. Earlier, Kyle Smith had added a light-sensitive protein to one small part of its brain – the infralimbic cortex (ILC). This addition allows Smith to silence the neurons in this one area with a flash of yellow light, delivered to the rat’s brain via an optic fibre. The light flashes for just three seconds, and the habit disappears. The rat hears the tone, but no longer heads down the chocolate arm.
The experiment shows that even though habits seem automatic, they still depend on ongoing supervision from the ILC and possibly other parts of the brain. They’re ingrained and durable, but subject to second-by-second control. And they can be disrupted in surprisingly quick and simple ways.
“We were all stunned by how immediate and on-line these effects really are,” says Smith. “Changing the activity of this small cortex area could profoundly change how habitual behaviour was, in a matter of seconds.”
By cutting out bits of a rodent’s brain, or inactivating them with chemicals, other scientists had already identified parts of the brain, including the ILC, that are important for habits. But these are somewhat clumsy methods. Smith’s team wanted some more refined, something that could inactivate the ILC on demand for short bursts of time.
They turned to optogenetics. This revolutionary technique takes light-sensitive proteins from around the tree of life, and uses viruses to introduce them into an animal’s neurons. By choosing the right protein, and targeting the right part of the brain, scientists can now excite or silence a chosen group of neurons with astounding precision, using little more than flashes of coloured light.
Working with supervisor Ann Graybiel and optogenetics founder Karl Deisseroth, Smith filled his rats’ ILCs with halorhodopsin – a protein that comes from salt-loving microbes, and silences neurons when hit by yellow light.
Smith then trained rats to run down one arm of his T-shaped maze towards some chocolate, or down the other towards a sugary drink. One tone set them off, and a second one told them which arm to run down. After days of practice, the habits became ingrained. Even when Smith started “devaluing” one of the rewards by lacing it with a nauseating chemical, the rat would still run towards it the next time it was tested, even if it didn’t drink. That’s a habit – a behavioural reflex. The tone sets off a chain of actions, regardless of what the rat gets out of them.
Roswell, UFOs and Project Pandora 2014 07 23 Well, now, this is interesting. In fact, it’s very interesting.
Over at the Department of Defense’s website you can find a file that has been declassified via the Freedom of Information Act on the subject of Project Pandora (which, to a significant degree, was focused on Cold War secrets, and how microwaves can affect the mind and body).
It’s a fascinating ...
Men of Europe, Put Down the Eckhart Tolle Book and Pick up Your Sword 2014 07 23 Remember who you really are...
The New Age Tactical Spiritual Military Industrial Complex supports murder and genocide. What is happening in Gaza today will eventually take place in London, Dublin, New York, Lisbon, Barcelona, Oslo, Glasgow, Melbourne, Stockholm, Auckland and Cape Town and wherever you are reading this article. Notice is being served upon all humanity. Not just the people of ...
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Unearthed in Inner Mongolia in 2002, Scansoriopteryx was previously classified as a theropod dinosaur, from which ...
Israeli Professor: Rape Hamas Militants’ Mothers and Sisters to Deter Terrorist Attacks 2014 07 23 An Israeli academic has claimed that raping wives and mothers of Palestinian Hamas militants is the only thing that could deter further terrorist attacks.
The remarks by renowned Middle East scholar Mordechai Kedar of Bar-Ilan University were made three weeks ago after the grim discovery of the bodies of the three kidnapped Israeli teenagers, but the recording was published online (in ...
’Mysterious plane’ with no callsign spotted circling London for two hours 2014 07 23 Scotland Yard has declined to comment on reports of a mysterious eavesdropping spyplane circling London.
A radar tracking website showed an aircraft orbiting London at 10,000 feet for more than two hours.
The plane had no recognisable callsign but was identified as a twin-engine Cessna F406 with the registration G-BVJT.
The aircraft has been linked in the past to a shadowy fleet of ...