Biologist discovers mammal with salamander-like regenerative abilities
2012 10 02
By Donna Hesterman | Phys.org
A small African mammal with an unusual ability to regrow damaged tissues could inspire new research in regenerative medicine, a University of Florida study finds.
For years biologists have studied salamanders for their ability to regrow lost limbs. But amphibian biology is very different than human biology, so lessons learned in laboratories from salamanders are difficult to translate into medical therapies for humans. New research in the Sept. 27 issue of the journal Nature describes a mammal that can regrow new body tissues following an injury.
The African spiny mouse could become a new model for research in regenerative medicine. "The African spiny mouse appears to regenerate ear tissue in much the way that a salamander regrows a limb that has been lost to a predator," said Ashley W. Seifert, a postdoctoral researcher in UF’s biology department. "Skin, hair follicles, cartilage—it all comes back."
That’s not the case in other mammals, he said. Usually scar tissue forms to fill the gap created by a wound.
The spiny mouse also regrows tissue on its main body when injured but not as completely as it does in its ears. "On their backs, they regrow hair follicles and skin, but the muscle beneath the skin doesn’t regenerate," Seifert said. Seifert was studying scar-free healing in amphibians when a colleague told him that a small rodent he had observed in Africa seemed capable of autotomy, a defense mechanism whereby the animal self-amputates a body part to escape a predator.
"Autotomy in skinks, geckos and some salamanders is well known," Seifert said. "But it is very rare in mammals, and so far we’ve only seen it in a few rodents that can jettison their tail."
Seifert’s colleague said that the African spiny mouse appeared to have tear-away skin that allowed it to slip a predator’s grasp. The notion was interesting enough to send Seifert packing to the Mpala Research Centre near Nairobi, Kenya. In Nairobi, Seifert was able to document the first known case of skin autotomy in a mammal.
But it was how the animals’ injuries appeared to be healing that really got his attention. Seifert used a 4mm biopsy punch, about the size of a large BB, to puncture holes in the ears of the mice to see if the animal showed regenerative capabilities. "The results were astonishing," he said.
"The various tissues in the ear grew back through formation of blastema-like structures—the same sort of biological process that a salamander uses to regenerate a severed limb." Ken Muneoka, a Tulane University professor of cell and molecular biology who was not involved with the study, agrees that Seifert’s findings are important.
"It could represent a new model system for skin wound healing and tissue regeneration in humans," he said.
Article from: phys.org
Nanomedicine Opens The Way For Nerve Cell Regeneration (2007)
Why chemotherapy doesn’t work - Cancer tumors confirmed to have stem cells that regenerate tumors
Scientists regenerate a plant -- 30,000 years on
Body’s Own Stem Cells Can Lead to Tooth Regeneration
Human Heart Regenerates Cells Automatically: One Percent Each Year
Pentagon Plan to Regrow Limbs: Phase One, Complete
’Spray-on skin’ has healing power
New Patch Makes Certain Skin Cancers Disappear
The man machines? Scientists develop plastic skin that BLEEDS red liquid - and can even heal itself
BulletProof Humans: Researcher and Artist Create Bulletproof Skin
Latest News from our Front Page
TWA Flight 800 Investigators Claim the Official Crash Story Is a Lie
2013 06 19
A new film claims the official government report on the crash of TWA Flight 800 in 1996 is an elaborate fabrication, but the most shocking part of the story is that charges are being leveled by some of the very investigators who put the report together. Six experts who appear in the film were members of the National Transportation Safety ...
The Great Pyramid of Giza as a monument of creation - Part 2: Water Element
2013 06 19
The Sphinx is not a mythical creature from Egyptian mythology and no ’half man/half lion’, but a lying, guardian lion who was worshiped. At the time of the life-giving floods of the Nile, the Sun and the constellation of Leo came both above the horizon in the east, and therefore the Sphinx was called the ’Guardian of the Sun’. In ...
So It Begins: Darpa Sets Out to Make Computers That Can Teach Themselves
2013 06 18
The Pentagon’s blue-sky research agency is readying a nearly four-year project to boost artificial intelligence systems by building machines that can teach themselves — while making it easier for ordinary schlubs like us to build them, too.
When Darpa talks about artificial intelligence, it’s not talking about modeling computers after the human brain. That path fell out of favor among computer ...
Atacama Humanoid: Stanford-Geneticist Says Specimen "not worth scrutiny"
2013 06 18
The documentary SIRIUS has intrigued and shocked many, and has stirred debate about the scientific findings regarding the ’Atacama Humanoid’.
Recently, daily German science news site GreWi.de followed up with Dr. Garry Nolan, the Stanford geneticist that headed the investigation into the mummified remains.
Since the documentary movie "Sirius" showed the first results of an investigation of a just 15 ...
The Illuminati Depopulation Agenda
2013 06 18
While the global elite construct underground bunkers, eat organic and hoard seeds in Arctic vaults; the global poor are being slowly starved thanks to high commodity prices and poisoned with genetically modified (GMO) food. Austerity measures aimed largely at the poor are being imposed on all the nations of the world. Weather events grow more deadly and brushfire wars more ...
|More News » |