Biologist discovers mammal with salamander-like regenerative abilities
2012-10-02 0:00

By Donna Hesterman | Phys.org





A small African mammal with an unusual ability to regrow damaged tissues could inspire new research in regenerative medicine, a University of Florida study finds.

For years biologists have studied salamanders for their ability to regrow lost limbs. But amphibian biology is very different than human biology, so lessons learned in laboratories from salamanders are difficult to translate into medical therapies for humans. New research in the Sept. 27 issue of the journal Nature describes a mammal that can regrow new body tissues following an injury.

The African spiny mouse could become a new model for research in regenerative medicine. "The African spiny mouse appears to regenerate ear tissue in much the way that a salamander regrows a limb that has been lost to a predator," said Ashley W. Seifert, a postdoctoral researcher in UF’s biology department. "Skin, hair follicles, cartilage—it all comes back."

That’s not the case in other mammals, he said. Usually scar tissue forms to fill the gap created by a wound.

The spiny mouse also regrows tissue on its main body when injured but not as completely as it does in its ears. "On their backs, they regrow hair follicles and skin, but the muscle beneath the skin doesn’t regenerate," Seifert said. Seifert was studying scar-free healing in amphibians when a colleague told him that a small rodent he had observed in Africa seemed capable of autotomy, a defense mechanism whereby the animal self-amputates a body part to escape a predator.

"Autotomy in skinks, geckos and some salamanders is well known," Seifert said. "But it is very rare in mammals, and so far we’ve only seen it in a few rodents that can jettison their tail."

Seifert’s colleague said that the African spiny mouse appeared to have tear-away skin that allowed it to slip a predator’s grasp. The notion was interesting enough to send Seifert packing to the Mpala Research Centre near Nairobi, Kenya. In Nairobi, Seifert was able to document the first known case of skin autotomy in a mammal.

But it was how the animals’ injuries appeared to be healing that really got his attention. Seifert used a 4mm biopsy punch, about the size of a large BB, to puncture holes in the ears of the mice to see if the animal showed regenerative capabilities. "The results were astonishing," he said.

"The various tissues in the ear grew back through formation of blastema-like structures—the same sort of biological process that a salamander uses to regenerate a severed limb." Ken Muneoka, a Tulane University professor of cell and molecular biology who was not involved with the study, agrees that Seifert’s findings are important.

"It could represent a new model system for skin wound healing and tissue regeneration in humans," he said.


Article from: phys.org






Related Articles
Nanomedicine Opens The Way For Nerve Cell Regeneration (2007)
Why chemotherapy doesn’t work - Cancer tumors confirmed to have stem cells that regenerate tumors
Scientists regenerate a plant -- 30,000 years on
Body’s Own Stem Cells Can Lead to Tooth Regeneration
Human Heart Regenerates Cells Automatically: One Percent Each Year
Pentagon Plan to Regrow Limbs: Phase One, Complete
’Spray-on skin’ has healing power
New Patch Makes Certain Skin Cancers Disappear
The man machines? Scientists develop plastic skin that BLEEDS red liquid - and can even heal itself
BulletProof Humans: Researcher and Artist Create Bulletproof Skin


Latest News from our Front Page

Netanyahu ‘spat in our face,’ White House officials said to say
2015-01-23 22:28
The White House’s outrage over Prime Minister Benjamin Netanyahu’s plan to speak before Congress in March — a move he failed to coordinate with the administration — began to seep through the diplomatic cracks on Friday, with officials telling Haaretz the Israeli leader had “spat” in President Barack Obama’s face. “We thought we’ve seen everything,” the newspaper quoted an unnamed senior ...
The Return of the Protected Jewish Minority in Europe
2015-01-23 2:53
Contrary to the standard narratives of Jewish ‘history,’ a prominent feature of the historical presence of Jews in Europe has been their protected status. The common context for this status was a symbiotic relationship between the Jewish minority and exploitative or tyrannical elites. As agents of the feared elite, as foreigners, as exploiters in their own right, and with interests ...
Truth Revealed: McCain’s ‘Moderate Rebels’ in Syria ARE ISIS
2015-01-23 1:50
Poor John McCain and Lindsey Graham, Washington’s real first couple. They only want to arm the ‘moderate opposition’ in Syria. Three years on, how come their master plan isn’t working, while ISIS has grown so strong? Despite what media lauded as, “the largest demonstration in France’s history – bigger than liberation at the end of WWII!” (can you rightly compare the ...
European 'No-Go' Zones: Fact or Fiction?
2015-01-22 0:37
Comment: This is an interesting article about Muslim no-go Zones in Europe. However, keep in mind that the focus in this piece is not addressing the root of the problem, but a symptom of the problem. Yes, there is an issue with large Islamic colonies in Europe today, but the article mentions nothing about who has changed the immigration laws ...
A Radical Traditionalist Critique of the Anti-Islam Movement
2015-01-22 0:20
The terrorist attack against the staff at the magazine Charlie Hebdo in Paris shook an entire continent. In a European climate in which protests against the perceived Islamization of our civilizational sphere becomes ever more widespread, showing in increased electoral success for moderate nationalist parties, as well as in expressions of mass public dissent, the recent resurgence of violent Islamic ...
More News »