|We are looking for Europeans of different nationalities that can speak about the refugee invasion in your country and how this REALLY is affecting you. Are you in Hungary, Greece, Germany, France, Italy, Austria or another country being heavily invaded? Please reach out: email@example.com or @rediceradio We want to speak with you!|
The drugs don’t work: a modern medical scandal
By Dr. Ben Goldacre | Guardian.co.uk
The doctors prescribing the drugs don’t know they don’t do what they’re meant to. Nor do their patients. The manufacturers know full well, but they’re not telling.
Reboxetine is a drug I have prescribed. Other drugs had done nothing for my patient, so we wanted to try something new. I’d read the trial data before I wrote the prescription, and found only well-designed, fair tests, with overwhelmingly positive results. Reboxetine was better than a placebo, and as good as any other antidepressant in head-to-head comparisons. It’s approved for use by the Medicines and Healthcare products Regulatory Agency (the MHRA), which governs all drugs in the UK. Millions of doses are prescribed every year, around the world. Reboxetine was clearly a safe and effective treatment. The patient and I discussed the evidence briefly, and agreed it was the right treatment to try next. I signed a prescription.
But we had both been misled. In October 2010, a group of researchers was finally able to bring together all the data that had ever been collected on reboxetine, both from trials that were published and from those that had never appeared in academic papers. When all this trial data was put together, it produced a shocking picture. Seven trials had been conducted comparing reboxetine against a placebo. Only one, conducted in 254 patients, had a neat, positive result, and that one was published in an academic journal, for doctors and researchers to read. But six more trials were conducted, in almost 10 times as many patients. All of them showed that reboxetine was no better than a dummy sugar pill. None of these trials was published. I had no idea they existed.
It got worse. The trials comparing reboxetine against other drugs showed exactly the same picture: three small studies, 507 patients in total, showed that reboxetine was just as good as any other drug. They were all published. But 1,657 patients’ worth of data was left unpublished, and this unpublished data showed that patients on reboxetine did worse than those on other drugs. If all this wasn’t bad enough, there was also the side-effects data. The drug looked fine in the trials that appeared in the academic literature; but when we saw the unpublished studies, it turned out that patients were more likely to have side-effects, more likely to drop out of taking the drug and more likely to withdraw from the trial because of side-effects, if they were taking reboxetine rather than one of its competitors.
I did everything a doctor is supposed to do. I read all the papers, I critically appraised them, I understood them, I discussed them with the patient and we made a decision together, based on the evidence. In the published data, reboxetine was a safe and effective drug. In reality, it was no better than a sugar pill and, worse, it does more harm than good. As a doctor, I did something that, on the balance of all the evidence, harmed my patient, simply because unflattering data was left unpublished.
Nobody broke any law in that situation, reboxetine is still on the market and the system that allowed all this to happen is still in play, for all drugs, in all countries in the world. Negative data goes missing, for all treatments, in all areas of science. The regulators and professional bodies we would reasonably expect to stamp out such practices have failed us. These problems have been protected from public scrutiny because they’re too complex to capture in a soundbite. This is why they’ve gone unfixed by politicians, at least to some extent; but it’s also why it takes detail to explain. The people you should have been able to trust to fix these problems have failed you, and because you have to understand a problem properly in order to fix it, there are some things you need to know.
Drugs are tested by the people who manufacture them, in poorly designed trials, on hopelessly small numbers of weird, unrepresentative patients, and analysed using techniques that are flawed by design, in such a way that they exaggerate the benefits of treatments. Unsurprisingly, these trials tend to produce results that favour the manufacturer. When trials throw up results that companies don’t like, they are perfectly entitled to hide them from doctors and patients, so we only ever see a distorted picture of any drug’s true effects. Regulators see most of the trial data, but only from early on in a drug’s life, and even then they don’t give this data to doctors or patients, or even to other parts of government. This distorted evidence is then communicated and applied in a distorted fashion.
In their 40 years of practice after leaving medical school, doctors hear about what works ad hoc, from sales reps, colleagues and journals. But those colleagues can be in the pay of drug companies – often undisclosed – and the journals are, too. And so are the patient groups. And finally, academic papers, which everyone thinks of as objective, are often covertly planned and written by people who work directly for the companies, without disclosure. Sometimes whole academic journals are owned outright by one drug company. Aside from all this, for several of the most important and enduring problems in medicine, we have no idea what the best treatment is, because it’s not in anyone’s financial interest to conduct any trials at all.
Now, on to the details.
Read the full article at: guardian.co.uk
Bad Pharma: How drug companies mislead doctors and harm patients (Amazon.co.uk), By Ben GoldAcre
Tune into Red Ice Radio:
Dr. Leonard Horowitz - The Pharmaceutical Industry, Vaccines & Frequency 528
Ian Crane - Codex Alimentarius, GMO and Artificial Food Scarcity
Ben Stewart - Esoteric Agenda
Dr. Andrew Saul - The War on Vitamins & Nutrition
David Crowe - Rethinking AIDS
Scott Tips - National Health Federation & Codex Alimentarius
Scott Tips - Codex Alimentarius Update Victory, Nutrient Reference Values & Swine Flu
Robin Falkov - Herbs, Health and Food Freedom & Radiation Defense
Kevin P Miller - Generation Rx, SSRI’s & Happy Pills
Latest News from our Front Page
College diversity officer charged for #KillAllWhiteMen tweet
A U.K. college diversity officer’s utopia would include no white men – after they are all executed.
An employee of Goldsmiths University of London’s independent students’ union was arrested in London Tuesday and charged with sending a menacing or offensive messages via a public network for her “#killallwhitemen” tweets.
Bahar Mustafa, 28, faces one charge each for electronic communications she sent over ...
Paedo deported from UK sneaked back and worked with kids for two years before being caught
Landazuri worked with teenagers for two years before he was caught
Juan Guerra Landazuri successfully lived in Britain with his new identity for two years and even got a job helping vulnerable teenagers - despite being banned from working with children for life.
The 44-year-old, originally known as Juan Alejandro Guerra, was jailed for four years in 2002 for two offences of ...
Why Don't More Minorities Hike?
As a Bay Area native, I grew up in outdoor spaces. While hiking trails in Tilden Park in the East Bay and in the Marin Headlands in the North Bay, I gained an appreciation of and respect for natural spaces that eventually led me to visit our national parksâ€”Yosemite being my favorite.
It was in Yosemite that I started to notice ...
NYU Professor: Fight climate change with hormone treatments on small children, 'closes the growth plates'
‘Interviewed on the Sunrise Weekend morning show, NYU Professor Matthew Liao promotes hormone treatments on children ‘when their small’ to close their ‘growth plates’ and thus stunt child growth.
Professor Liao says this helps fight climate change since ‘larger people consume more energy than smaller people.”
Varg Vikernes on Compassion
YouTube description: About Survivalism for Europeans. About Christian apologists. Learn how to act without any compassion with MYFAROG
|More News » |