They beat like real heart cells, but the rat cardiomyocytes in a dish at Harvard University are different in one crucial way. Snaking through them are wires and transistors that spy on each cellís electrical impulses. In future, the wires might control their behaviour too.
Versions of this souped-up, "cyborg" tissue have been created for neurons, muscle and blood vessels. They could be used to test drugsMovie Camera or as the basis for more biological versions of existing implants such as pacemakers. If signals can also be sent to the cells, cyborg tissue could be used in prosthetics or to create tiny robots.
"It allows one to effectively blur the boundary between electronic, inorganic systems and organic, biological ones," says Charles Lieber, who leads the team behind the cyborg tissue.
Artificial tissue can already be grown on three-dimensional scaffolds made of biological materials that are not electrically active. And electrical components have been added to cultured tissue before, but not integrated into its structure, so they were only able to glean information from the surface.
Bio-scaffolds go electric
Bioengineers at Harvard University have created the first examples of cyborg tissue: Neurons, heart cells, muscle, and blood vessels that are interwoven by nanowires and transistors. Source
Lieberís team combined these strands of work to create electrically active scaffolds. They created 3D networks of conductive nanowires studded with silicon sensors. Crucially, the wires had to be flexible and extremely small, to avoid impeding the growth of tissue. The scaffold also contained traditional biological materials such as collagen.
The researchers were able to grow rat neurons, heart cells and muscle in these hybrid meshes. In the case of the heart cells, they started to contract just like normal cells, and the researchers used the network to read out the rate of the beats.
When they added a drug that stimulates heart cell contraction, they detected an increase in the rate, indicating the tissue was behaving like normal and that the network could sense such changes.
Lieberís team also managed to grow an entire blood vessel about 1.5 centimetres long from human cells, with wires snaking through it. By recording electrical signals from inside and outside the vesselĖ something that was never possible beforeĖ the team was able to detect electrical patterns that they say could give clues to inflammation, whether tissue has undergone changes that make it prone to tumour formation or suggest impending heart disease.
Professor: Reason Itself Is A White Male Construct 2015-07-04 3:55
A philosophy and religion professor at Syracuse University gave an interview to The New York Times Thursday in which he critiqued the notion of pure reason as simply being a “white male Euro-Christian construction.”
Prof. John Caputo was being interviewed by fellow philosophy professor George Yancy for the 13th installment of an interview series Yancy conducts with philosophers regarding racial topics.
Given its emphasis on first principles ...
The Broken Window Fallacy 2015-07-04 3:48
Youtube description: This short video explains one of the most persistent economic fallacies of our day.
Jenji Kohan and the Jewish Hyper-Sexualization of Western Culture 2015-07-04 3:33
As detailed in The Culture of Critique, Freud and his followers regarded anti-Semitism was a universal pathology which had its roots in sexual repression. The theoretical basis for this can be found in Freud’s Three Essays on the Theory of Sexuality where he linked aggression to the frustration of human drives — especially the sex drive. Kevin MacDonald notes that: ...
Confederate History - Dispelling the Myths 2015-07-03 3:28
History books, the media, the school systems, etc abound in falsehoods and inaccuracies of Confederate and Southern history. This fact sheet will help to clarify and dispell some of these rampant inaccuracies.
MYTH - The War of 1861 - 1865 was fought over slavery.
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Gays Rights May Open Door for Pedophile Rights 2015-07-03 3:31
Democrats have attempted to normalize pedophilia as a sexual orientation.
A recent Supreme Court ruling on same-sex marriage may soon allow pedophiles to argue they are suffering discrimination.
‚ÄúUsing the same tactics used by ‚Äėgay‚Äô rights activists, pedophiles have begun to seek similar status arguing their desire for children is a sexual orientation no different than heterosexual or homosexuals,‚ÄĚ writes Jack Minor ...