Two Men Are HIV-Free After Undergoing Bone Marrow Transplants
2012-07-27 0:00

By Amanda Gardner | HealthDay

Following bone marrow transplants, two men infected with HIV no longer have any traces of the AIDS-causing virus in their lymphocytes, researchers report.

Lymphocytes are a type of white blood cell and are a key part of the immune system.

The U.S. researchers suspect that bone marrow transplantation along with continuation of antiretroviral therapy resulted in the dramatic effects evident eight months post-transplant. They are scheduled to present these preliminary findings Thursday at the International AIDS Conference in Washington, D.C.

HIV patients on antiretroviral therapy often achieve "undetectable viral loads," meaning there are no virus particles in their blood. But they still have latent HIV in their lymphocytes, and if antiretroviral therapy were discontinued, the latent HIV could reactivate.

But having no traces of HIV in these white blood cells is an indication that this "reservoir" of latent HIV may have been eliminated, the researchers believe.

At this point, they are far from saying these patients are cured. But the findings are "exciting," said Dr. Savita Pahwa, director of the Center for AIDS Research at the University of Miami Miller School of Medicine, who was not involved with the study.

"Every hint you get that it’s possible to wipe out the reservoir needs to be investigated," she said.

"Eliminating the reservoir is the key to the cure," said Pahwa. She also stressed that it would only be possible to say these patients were "functionally cured" if the virus did not rebound when the patients went off antiretroviral therapy.

The two men whose cases are described in the paper underwent chemotherapy for blood cancers before receiving stem cell transplants. One had his transplant two years ago; the other, four years ago. Both also developed graft-versus-host disease (when transplanted cells attack the host cells) and continued with their antiretroviral medications throughout and after the transplant procedures.

Any of these factors could theoretically explain their HIV-free status, but the bone marrow transplantation combined with antiretroviral therapy seems the most likely explanation, said the study authors.

[...]


Read the full article at: health.usnews.com





Man Cured of AIDS: ’I Feel Good’






Related Articles
War on drugs making HIV epidemic worse, group says
Vatican: Condom use less evil than spreading HIV
Did doctors jumpstart the HIV pandemic?
The Berlin Patient Cured of AIDS?


Latest News from our Front Page

Not Again: More US AID, Missiles Shipped to al Qaeda, al Nusra and ISIS in Syria, Iraq
2015-03-06 4:28
Two weeks ago, 21WIRE reported on how ISIS and other terrorists militants operating in Syria and Iraq are receiving regular weapons and ‘supply drops’ – forming a ‘rat line’ which seems to be playing a crucial role in keeping this highly profitable conflict going on both sides. This week, it’s been reported that Jabhat Al-Nusra fighters have been brandishing US-supplied ...
Swedish parliament removes Baroque artist's bare breasted painting for offending feminists and Muslims
2015-03-06 3:28
A nude painting named Juno, which was painted by baroque artist G E Schröder and has hung in the dining room of the Swedish Parliament for 30 years has been taken down for fear of offending the sensitivities of feminists and Muslim visitors, Swedish newspaper, The Local reported on Thursday. Explaining the ban on the baroque breasts, a source from the ...
White US children will be minorities by 2020 after immigrant 'baby boom', Census reveals
2015-03-05 19:50
This is the result of an ongoing trend of declining birth among white Americans and a baby boom among immigrant groups, as well as a surge in immigration. By the year 2020, 50.2percent of all children in the US are expected to be non-white, according to the Census. By 2044, whites will be outnumbered by minorities. The Census study, released ...
New Jersey Shopkeeper Hangs 'White History Month' Sign In Window
2015-03-05 18:08
A deli owner in Flemington, New Jersey, has angered many of his neighbors by posting a sign on his window that reads, "Celebrate Your White Heritage in March White History Month." Jim Boggess, who is the owner of Jimbo's Deli, says he put up the sign to remind everyone that they should be proud of their race and culture. "No matter what ...
The Viking ”Maine Penny” Mystery
2015-03-05 3:41
In 1957, during his second year of digging at the Goddard site; a large prehistoric Indian trade village in Penobscot Bay on the central Maine coast, local resident and amateur archaeologist Guy Mellgren found a small silver coin. The coin is later identified by experts as a Norse silver penny dating to the reign of Olaf Kyrre, king of Norway ...
More News »