Two Men Are HIV-Free After Undergoing Bone Marrow Transplants
2012-07-27 0:00

By Amanda Gardner | HealthDay

Following bone marrow transplants, two men infected with HIV no longer have any traces of the AIDS-causing virus in their lymphocytes, researchers report.

Lymphocytes are a type of white blood cell and are a key part of the immune system.

The U.S. researchers suspect that bone marrow transplantation along with continuation of antiretroviral therapy resulted in the dramatic effects evident eight months post-transplant. They are scheduled to present these preliminary findings Thursday at the International AIDS Conference in Washington, D.C.

HIV patients on antiretroviral therapy often achieve "undetectable viral loads," meaning there are no virus particles in their blood. But they still have latent HIV in their lymphocytes, and if antiretroviral therapy were discontinued, the latent HIV could reactivate.

But having no traces of HIV in these white blood cells is an indication that this "reservoir" of latent HIV may have been eliminated, the researchers believe.

At this point, they are far from saying these patients are cured. But the findings are "exciting," said Dr. Savita Pahwa, director of the Center for AIDS Research at the University of Miami Miller School of Medicine, who was not involved with the study.

"Every hint you get that it’s possible to wipe out the reservoir needs to be investigated," she said.

"Eliminating the reservoir is the key to the cure," said Pahwa. She also stressed that it would only be possible to say these patients were "functionally cured" if the virus did not rebound when the patients went off antiretroviral therapy.

The two men whose cases are described in the paper underwent chemotherapy for blood cancers before receiving stem cell transplants. One had his transplant two years ago; the other, four years ago. Both also developed graft-versus-host disease (when transplanted cells attack the host cells) and continued with their antiretroviral medications throughout and after the transplant procedures.

Any of these factors could theoretically explain their HIV-free status, but the bone marrow transplantation combined with antiretroviral therapy seems the most likely explanation, said the study authors.

[...]


Read the full article at: health.usnews.com





Man Cured of AIDS: ’I Feel Good’






Related Articles
War on drugs making HIV epidemic worse, group says
Vatican: Condom use less evil than spreading HIV
Did doctors jumpstart the HIV pandemic?
The Berlin Patient Cured of AIDS?


Latest News from our Front Page

Facebook completes first drone flight above UK, Mark Zuckerberg confirms
2015-03-28 3:15
Solar powered drones which provide internet access to rural and remote areas have been trialled in UK for first time by Facebook. They “have a wingspan greater than a Boeing 737 but will weigh less than a car”, according to the social network's chief Mark Zuckerberg. The drones, developed by Somerset-based company Ascenta which Facebook bought last March, will beam down laser-guided ...
300 Young English Girls (and a few Boys) Groomed and Assaulted by Oxfordshire "Gangs," Report Finds
2015-03-28 2:04
Editor's note: This story is a few days old now but the echoes of Rotherham just keeps coming. A few weeks ago there was Halifax, now Britain proudly can add Oxfordshire to their line up of diversity success stories. Below is the story from the telegraph: Serious case review finds failings by police and social services as it identifies hundreds of victims A ...
British POW describes the horror of the bombing of Dresden
2015-03-28 0:33
Partial Transcript of Interview with Victor Gregg, WW2 British solder and POW: Interviewer: "Tell us how it was that you were in Dresden at that time." Victor Gregg: "It was evil....thousands of firebombs dropping all over the place, heat, fire, people screaming, people burning, people alight. After about half an hour it started developing into something that was really bad....It was ...
Rape of 285,000 German Women at the End of WWII Trigger Damage Control by Mainstream Media
2015-03-27 20:25
Is Exposing Allied War Crimes an honorable act? No, it’s slandering heroes according to Daily Mail A recent article from the Daily Mail that pretends to look at the post WWII crimes and rapes of the Allies against the German people is actually damage control. It’s really an attempt to divert away from the true horrors that was visited upon Germany ...
Minister of Migration attacked by asylum seeker with fire extinguisher
2015-03-27 2:12
Sweden’s Minister of Justice & Migration also known as Morgan “only 1%” Johansson, has been attacked with a fire extinguisher when he visited an asylum home for future Swedes. Regional newspaper, Kristiandstadsbladet reported that a man who had been living at the home for a couple of weeks grabbed a fire extinguisher and sprayed foam all over the minister who didn’t ...
More News »