Scientists grow sperm in a lab
2011 03 28
By Ian Sample | Guardian.co.uk
Mouse sperm were grown using a technique that could also help preserve the fertility of boys undergoing cancer treatment.
Scientists have grown sperm in the laboratory in a landmark study that could help preserve the fertility of cancer patients and shed fresh light on male reproductive problems.
Fertility experts called the work a "crucial experimental advance" towards the use of lab-grown sperm in the clinic and a stepping stone to the routine creation of human sperm for men who cannot make the cells normally.
Though the procedure would be illegal in Britain under current legislation, sperm grown in the laboratory, if proven safe, could be used to help infertile men have children through standard IVF treatments.
The procedure could also benefit boys with cancer who are too young to produce sperm but are at risk of being made infertile by radio- or chemotherapy.
While men can have their sperm frozen before cancer treatment, the latest research suggests boys could have testicular tissue removed and kept in cold storage for use in later life.
Japanese researchers cultivated small pieces of tissue from the testes of baby mice on a gel bathed in nutrients. After several weeks they collected viable sperm from the tissue.
Scientists Grow Sperm in Lab
Video from: YouTube.com
The sperm appeared to be completely healthy and were used in IVF treatments to produce 12 live mouse pups that went on to have young of their own. Seven of the mice were born after sperm heads were transferred into 23 eggs using a technique called round spermatid injection, and another five were born after 35 eggs were fertilised using intracytoplasmic sperm injection (Icsi), a common IVF procedure.
Importantly, the scientists retrieved healthy sperm from tissue that was cultivated after being frozen for up to 25 days, suggesting that cold storage did not harm the cells. The work, reported in the journal, Nature, is the most successful attempt yet to grow mammalian sperm from testicular tissue in the laboratory.
"One of the problems I face, as a urologist, is that we do not have any effective ways to treat patients suffering from male infertility due to defective or insufficient sperm production," said Takehiko Ogawa, who led the study at Yokohama City University Graduate School of Medicine. "Most of these problems are for unknown reasons."
Using the technique, he said, scientists will be able to study the process of sperm production in detail and help elucidate the glitches that cause infertility.
In an accompanying article, Marco Seandel and Shahin Rafii at the Weil Cornell Medical College in New York said the work was "a crucial experimental advance along the thorny path to the clinical use of sperm" grown in the lab. They warn, however, that the fertility of mouse pups born from the lab-grown sperm was a "crude indicator" of their health, and that subtle genetic changes in the sperm "could be pivotal for the wellbeing of subsequent generations".
Allan Pacey, a senior lecturer in andrology at Sheffield University, said: "It is not totally clear how sperm are formed and why in some men it doesn’t work properly. This could help discover new drugs or treatments to stimulate infertile men to produce more or better sperm. It also may help preserve the fertility of some males."
The study, he said, was "a small but important step in understanding how sperm are formed which may, in time, lead to us being able to routinely grow human sperm in the laboratory."
"It is clearly important to make sure that any sperm produced are safe and give rise to healthy offspring when used, and that they in turn have healthy offspring. We need to be cautious with this kind of work," he added.
Article from: guardian.co.uk
Eugenics - Human Sperm Created in British Lab (2009)
Eugenics - Human Sperm Created in British Lab (Embryonic Stem Cells)
Video from: YouTube.com
US clinic offers British couples the chance to choose the sex of their child
Hybrid embryos could be created within months
Baby Born From 20-Year-Old Frozen Embryo
Dating Website for ’Beautiful People’ Aims at "Noble Cause" Designer Babies
The Disappearing Male (Video)
Young women are freezing their fat so they can use it to firm and boost their bodies 30 years later
British fertility clinic raffling human egg
Woman offered ’£200 to be sterilized’
Latest News from our Front Page
Illegal Aliens Cleared For U.S. Military Service
2014 10 18
The Pentagon announced a new policy allowing illegal immigrants the opportunity to enlist in the armed forces, Thursday.
USA Today reports that the new recruitment policies will focus on people with "high-demand skills" like foreign language acumen and health care training:
"For the first time, the program — known as Military Accessions in the National Interest, or MAVNI — will ...
Bronze Age Sundial-Moondial Discovered in Russia
2014 10 16
A strange slab of rock discovered in Russia more than 20 years ago appears to be a combination sundial and moondial from the Bronze Age, a new study finds.
The slab is marked with round divots arranged in a circle, and an astronomical analysis suggests that these markings coincide with heavenly events, including sunrises and moonrises.
The sundial might be "evidence of ...
Humans may only survive 68 days on Mars
2014 10 15
Space enthusiasts planning a move to Mars may have to wait to relocate: conditions on the Red Planet are such that humans would likely begin dying within 68 days, a new study says.
Oxygen levels would start to deplete after about two months and scientists said new technologies are required before humans can permanently settle on Mars, according to the study ...
Tom Sunic’s letter to the US Ambassador to Hungary
2014 10 14
October 11, 2014
Mr. André Goodfriend
Embassy of the United States of America
Szabadság tér 12
Dear Mr. Goodfriend,
As an American citizen I would hereby like to express my concern over the recent decision by the Hungarian government to ban the National Policy Institute (NPI) conference which had been scheduled to take place in Budapest from October 3 to October 5, 2014. ...
"Vampire grave" found in Bulgaria
2014 10 14
A "vampire grave" containing a skeleton with a stake driven through its chest has been unearthed by a man known as "Bulgaria’s Indiana Jones".
Professor Nikolai Ovcharov – a crusading archaeologist who has dedicated his life to unearthing mysteries of ancient civilisations – said that he had made the discovery while excavating the ruins of Perperikon, an ancient Thracian city ...
|More News » |